RFX6 protein (Erinaceus europaeus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

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[Homology]

Score

RFX6

DNA-binding protein RFX6. (932 aa)

Predicted Functional Partners:

ENSEEUP00000006558

0.876

ENSEEUP00000002216

0.812

ATR

0.794

ANKRA2

0.776

ENSEEUP00000007264

0.770

HHEX

0.768

RFX7

0.737

PCSK1

0.719

TONSL

0.681

ONECUT1

0.671

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRA2	ENSEEUP00000006558	ENSEEUP00000007450	ENSEEUP00000006558	Ankyrin repeat family A protein 2 isoform X2.	annotation not available	0.920
ANKRA2	RFX6	ENSEEUP00000007450	ENSEEUP00000001772	Ankyrin repeat family A protein 2 isoform X2.	DNA-binding protein RFX6.	0.776
ANKRA2	RFX7	ENSEEUP00000007450	ENSEEUP00000012500	Ankyrin repeat family A protein 2 isoform X2.	DNA-binding protein RFX7.	0.927
ANKRA2	TONSL	ENSEEUP00000007450	ENSEEUP00000000446	Ankyrin repeat family A protein 2 isoform X2.	Tonsoku-like protein.	0.497
ATR	ENSEEUP00000002216	ENSEEUP00000010962	ENSEEUP00000002216	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	annotation not available	0.993
ATR	RFX6	ENSEEUP00000010962	ENSEEUP00000001772	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	DNA-binding protein RFX6.	0.794
ATR	RFX7	ENSEEUP00000010962	ENSEEUP00000012500	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	DNA-binding protein RFX7.	0.721
ENSEEUP00000002216	ATR	ENSEEUP00000002216	ENSEEUP00000010962	annotation not available	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	0.993
ENSEEUP00000002216	RFX6	ENSEEUP00000002216	ENSEEUP00000001772	annotation not available	DNA-binding protein RFX6.	0.812
ENSEEUP00000002216	RFX7	ENSEEUP00000002216	ENSEEUP00000012500	annotation not available	DNA-binding protein RFX7.	0.801
ENSEEUP00000006558	ANKRA2	ENSEEUP00000006558	ENSEEUP00000007450	annotation not available	Ankyrin repeat family A protein 2 isoform X2.	0.920
ENSEEUP00000006558	RFX6	ENSEEUP00000006558	ENSEEUP00000001772	annotation not available	DNA-binding protein RFX6.	0.876
ENSEEUP00000006558	RFX7	ENSEEUP00000006558	ENSEEUP00000012500	annotation not available	DNA-binding protein RFX7.	0.796
ENSEEUP00000006558	TONSL	ENSEEUP00000006558	ENSEEUP00000000446	annotation not available	Tonsoku-like protein.	0.741
ENSEEUP00000007264	ONECUT1	ENSEEUP00000007264	ENSEEUP00000009211	annotation not available	One cut domain family member.	0.438
ENSEEUP00000007264	RFX6	ENSEEUP00000007264	ENSEEUP00000001772	annotation not available	DNA-binding protein RFX6.	0.770
ENSEEUP00000007264	RFX7	ENSEEUP00000007264	ENSEEUP00000012500	annotation not available	DNA-binding protein RFX7.	0.489
HHEX	RFX6	ENSEEUP00000002759	ENSEEUP00000001772	Hematopoietically-expressed homeobox protein HHEX.	DNA-binding protein RFX6.	0.768
ONECUT1	ENSEEUP00000007264	ENSEEUP00000009211	ENSEEUP00000007264	One cut domain family member.	annotation not available	0.438
ONECUT1	RFX6	ENSEEUP00000009211	ENSEEUP00000001772	One cut domain family member.	DNA-binding protein RFX6.	0.671

page 1 of 3

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

6 of 143

1.2

1.18

0.00017

GO:0050896

Response to stimulus

9 of 320

1.03

1.14

2.79e-06

GO:0050794

Regulation of cellular process

10 of 417

0.96

1.05

1.33e-06

GO:0000160

Phosphorelay signal transduction system

4 of 80

1.28

0.9

0.0058

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016772

Transferase activity, transferring phosphorus-containing groups

5 of 171

1.04

0.58

0.0315

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

8 of 731

0.62

0.43

0.0116

GO:0016020

Membrane

9 of 1060

0.51

0.36

0.0116

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2286

His Kinase A (phosphoacceptor) domain, and PAS-associated, C-terminal

11 of 30

2.14

7.51

1.73e-20

CL:2287

His Kinase A (phosphoacceptor) domain, and PAS fold

9 of 25

2.13

6.36

1.89e-16

CL:2288

PAS-associated, C-terminal, and His Kinase A (phosphoacceptor) domain

6 of 18

2.1

4.22

3.75e-10

CL:2308

His Kinase A (phosphoacceptor) domain

3 of 8

2.15

2.05

9.45e-05

CL:2289

PAS-associated, C-terminal

3 of 10

2.05

1.91

0.00016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 332

1.01

1.15

8.50e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045121

Membrane raft

2 of 4

2.28

1.06

0.0110

GOCC:0016020

Membrane

8 of 515

0.77

0.61

0.0016

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

9 of 62

1.74

3.97

4.21e-13

KW-0418

Kinase

10 of 88

1.63

3.66

7.67e-14

KW-0175

Coiled coil

7 of 416

0.8

0.65

0.0013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005467

Histidine kinase domain

10 of 38

2.0

5.76

2.20e-16

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

9 of 31

2.04

5.6

4.75e-15

IPR003594

Histidine kinase/HSP90-like ATPase

10 of 46

1.91

5.28

5.97e-16

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 27

2.05

5.1

3.22e-13

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

10 of 54

1.84

4.87

1.69e-15

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

9 of 32

2.03

5.73

9.57e-16

SM00387

Histidine kinase-like ATPases

10 of 52

1.86

5.1

2.83e-16

SM00448

cheY-homologous receiver domain

9 of 53

1.81

4.45

3.66e-14

SM00091

PAS domain

5 of 38

1.7

2.39

1.06e-06

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 30

1.58

1.27

0.0015

(more ...)

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