STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TNFErinaceus europaeus tumor necrosis factor (TNF), mRNA. (232 aa)    
Predicted Functional Partners:
TNFRSF11B
Tumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis.
   
 0.824
CD40
Tumor necrosis factor receptor superfamily member 5.
   
 0.824
TNFRSF1B
Tumor necrosis factor receptor superfamily member 1B.
     
 0.819
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
   
  
 0.786
PLEKHG5
Pleckstrin homology domain-containing family G member 5 isoform X2.
    
 0.759
PLEKHG6
Pleckstrin homology and RhoGEF domain containing G6.
    
 0.759
LZTR1
Leucine-zipper-like transcriptional regulator 1 isoform X1.
    
 0.719
IL6
Interleukin-6.
   
  
 0.715
LTA
Lymphotoxin-alpha; Belongs to the tumor necrosis factor family.
  
 
 
0.685
ENSEEUP00000005625
annotation not available
    
 0.683
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.