ORMDL3 protein (Erinaceus europaeus) - STRING interaction network

Nodes:

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second shell of interactors

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Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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Score

ORMDL3

ORM1-like protein; Negative regulator of sphingolipid synthesis. (153 aa)

Predicted Functional Partners:

SPTLC1

0.939

SPTSSA

0.918

SPTLC3

0.825

SPTLC2

0.825

ENSEEUP00000005960

0.779

ZPBP2

0.648

LRRC3C

0.645

ISM1

0.637

ENSEEUP00000008643

0.637

ENSEEUP00000011411

0.577

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEUP00000005960	LRRC3C	ENSEEUP00000005960	ENSEEUP00000012129	annotation not available	Leucine-rich repeat-containing protein 3C.	0.688
ENSEEUP00000005960	ORMDL3	ENSEEUP00000005960	ENSEEUP00000003711	annotation not available	ORM1-like protein; Negative regulator of sphingolipid synthesis.	0.779
ENSEEUP00000005960	ZPBP2	ENSEEUP00000005960	ENSEEUP00000005848	annotation not available	Zona pellucida-binding protein 2.	0.804
ENSEEUP00000008643	ORMDL3	ENSEEUP00000008643	ENSEEUP00000003711	annotation not available	ORM1-like protein; Negative regulator of sphingolipid synthesis.	0.637
ENSEEUP00000011411	ORMDL3	ENSEEUP00000011411	ENSEEUP00000003711	annotation not available	ORM1-like protein; Negative regulator of sphingolipid synthesis.	0.577
ENSEEUP00000011411	SPTLC1	ENSEEUP00000011411	ENSEEUP00000011224	annotation not available	Serine palmitoyltransferase 1 isoform X2.	0.459
ENSEEUP00000011411	SPTLC3	ENSEEUP00000011411	ENSEEUP00000009634	annotation not available	Serine palmitoyltransferase 3.	0.520
ENSEEUP00000011411	SPTSSA	ENSEEUP00000011411	ENSEEUP00000005262	annotation not available	Serine palmitoyltransferase small subunit A.	0.671
ISM1	ORMDL3	ENSEEUP00000001853	ENSEEUP00000003711	Isthmin-1.	ORM1-like protein; Negative regulator of sphingolipid synthesis.	0.637
ISM1	SPTLC1	ENSEEUP00000001853	ENSEEUP00000011224	Isthmin-1.	Serine palmitoyltransferase 1 isoform X2.	0.964
ISM1	SPTSSA	ENSEEUP00000001853	ENSEEUP00000005262	Isthmin-1.	Serine palmitoyltransferase small subunit A.	0.786
LRRC3C	ENSEEUP00000005960	ENSEEUP00000012129	ENSEEUP00000005960	Leucine-rich repeat-containing protein 3C.	annotation not available	0.688
LRRC3C	ORMDL3	ENSEEUP00000012129	ENSEEUP00000003711	Leucine-rich repeat-containing protein 3C.	ORM1-like protein; Negative regulator of sphingolipid synthesis.	0.645
LRRC3C	ZPBP2	ENSEEUP00000012129	ENSEEUP00000005848	Leucine-rich repeat-containing protein 3C.	Zona pellucida-binding protein 2.	0.771
ORMDL3	ENSEEUP00000005960	ENSEEUP00000003711	ENSEEUP00000005960	ORM1-like protein; Negative regulator of sphingolipid synthesis.	annotation not available	0.779
ORMDL3	ENSEEUP00000008643	ENSEEUP00000003711	ENSEEUP00000008643	ORM1-like protein; Negative regulator of sphingolipid synthesis.	annotation not available	0.637
ORMDL3	ENSEEUP00000011411	ENSEEUP00000003711	ENSEEUP00000011411	ORM1-like protein; Negative regulator of sphingolipid synthesis.	annotation not available	0.577
ORMDL3	ISM1	ENSEEUP00000003711	ENSEEUP00000001853	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Isthmin-1.	0.637
ORMDL3	LRRC3C	ENSEEUP00000003711	ENSEEUP00000012129	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Leucine-rich repeat-containing protein 3C.	0.645
ORMDL3	SPTLC1	ENSEEUP00000003711	ENSEEUP00000011224	ORM1-like protein; Negative regulator of sphingolipid synthesis.	Serine palmitoyltransferase 1 isoform X2.	0.939

page 1 of 3

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

6 of 143

1.2

1.18

0.00017

GO:0050896

Response to stimulus

9 of 320

1.03

1.14

2.79e-06

GO:0050794

Regulation of cellular process

10 of 417

0.96

1.05

1.33e-06

GO:0000160

Phosphorelay signal transduction system

4 of 80

1.28

0.9

0.0058

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016772

Transferase activity, transferring phosphorus-containing groups

5 of 171

1.04

0.58

0.0315

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

8 of 731

0.62

0.43

0.0116

GO:0016020

Membrane

9 of 1060

0.51

0.36

0.0116

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2286

His Kinase A (phosphoacceptor) domain, and PAS-associated, C-terminal

11 of 30

2.14

7.51

1.73e-20

CL:2287

His Kinase A (phosphoacceptor) domain, and PAS fold

9 of 25

2.13

6.36

1.89e-16

CL:2288

PAS-associated, C-terminal, and His Kinase A (phosphoacceptor) domain

6 of 18

2.1

4.22

3.75e-10

CL:2308

His Kinase A (phosphoacceptor) domain

3 of 8

2.15

2.05

9.45e-05

CL:2289

PAS-associated, C-terminal

3 of 10

2.05

1.91

0.00016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 332

1.01

1.15

8.50e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045121

Membrane raft

2 of 4

2.28

1.06

0.0110

GOCC:0016020

Membrane

8 of 515

0.77

0.61

0.0016

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

9 of 62

1.74

3.97

4.21e-13

KW-0418

Kinase

10 of 88

1.63

3.66

7.67e-14

KW-0175

Coiled coil

7 of 416

0.8

0.65

0.0013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005467

Histidine kinase domain

10 of 38

2.0

5.76

2.20e-16

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

9 of 31

2.04

5.6

4.75e-15

IPR003594

Histidine kinase/HSP90-like ATPase

10 of 46

1.91

5.28

5.97e-16

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 27

2.05

5.1

3.22e-13

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

10 of 54

1.84

4.87

1.69e-15

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

9 of 32

2.03

5.73

9.57e-16

SM00387

Histidine kinase-like ATPases

10 of 52

1.86

5.1

2.83e-16

SM00448

cheY-homologous receiver domain

9 of 53

1.81

4.45

3.66e-14

SM00091

PAS domain

5 of 38

1.7

2.39

1.06e-06

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 30

1.58

1.27

0.0015

(more ...)

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