node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AAR2 | DYRK1A | ENSEEUP00000003865 | ENSEEUP00000000676 | Protein AAR2 homolog. | Dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2. | 0.560 |
AAR2 | ENSEEUP00000005089 | ENSEEUP00000003865 | ENSEEUP00000005089 | Protein AAR2 homolog. | annotation not available | 0.768 |
ATM | DYRK1A | ENSEEUP00000007164 | ENSEEUP00000000676 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2. | 0.587 |
ATM | ENSEEUP00000005089 | ENSEEUP00000007164 | ENSEEUP00000005089 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | annotation not available | 0.663 |
ATM | MDM4 | ENSEEUP00000007164 | ENSEEUP00000012689 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family. | 0.880 |
ATM | RIPK2 | ENSEEUP00000007164 | ENSEEUP00000007701 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. | 0.433 |
ATM | SUMO1 | ENSEEUP00000007164 | ENSEEUP00000011981 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Small ubiquitin-related modifier. | 0.788 |
ATM | TP53 | ENSEEUP00000007164 | ENSEEUP00000013295 | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.996 |
CHCHD3 | ENSEEUP00000005089 | ENSEEUP00000004068 | ENSEEUP00000005089 | MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. | annotation not available | 0.640 |
CLK2 | ENSEEUP00000005089 | ENSEEUP00000001436 | ENSEEUP00000005089 | CDC like kinase 2. | annotation not available | 0.899 |
DYRK1A | AAR2 | ENSEEUP00000000676 | ENSEEUP00000003865 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2. | Protein AAR2 homolog. | 0.560 |
DYRK1A | ATM | ENSEEUP00000000676 | ENSEEUP00000007164 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.587 |
DYRK1A | ENSEEUP00000005089 | ENSEEUP00000000676 | ENSEEUP00000005089 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2. | annotation not available | 0.903 |
DYRK1A | RIPK2 | ENSEEUP00000000676 | ENSEEUP00000007701 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2. | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. | 0.437 |
DYRK1A | SUMO1 | ENSEEUP00000000676 | ENSEEUP00000011981 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2. | Small ubiquitin-related modifier. | 0.642 |
DYRK1A | TP53 | ENSEEUP00000000676 | ENSEEUP00000013295 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X2. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.666 |
ENSEEUP00000005089 | AAR2 | ENSEEUP00000005089 | ENSEEUP00000003865 | annotation not available | Protein AAR2 homolog. | 0.768 |
ENSEEUP00000005089 | ATM | ENSEEUP00000005089 | ENSEEUP00000007164 | annotation not available | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.663 |
ENSEEUP00000005089 | CHCHD3 | ENSEEUP00000005089 | ENSEEUP00000004068 | annotation not available | MICOS complex subunit; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. | 0.640 |
ENSEEUP00000005089 | CLK2 | ENSEEUP00000005089 | ENSEEUP00000001436 | annotation not available | CDC like kinase 2. | 0.899 |