STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ITCHE3 ubiquitin-protein ligase. (836 aa)    
Predicted Functional Partners:
NUMB
Protein numb homolog isoform X1.
    
 0.977
CFLAR
LOW QUALITY PROTEIN: CASP8 and FADD-like apoptosis regulator; Belongs to the peptidase C14A family.
    
 0.972
WWP1
E3 ubiquitin-protein ligase.
  
 
0.969
RPS27A
ubiquitin-40S ribosomal protein S27a.
    
 0.966
ERBB4
Receptor protein-tyrosine kinase.
    
 0.953
TRAF6
TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.
    
 0.948
LOC103127499
RING finger protein 11.
    
 
 0.917
NEDD4
E3 ubiquitin-protein ligase NEDD4.
  
 
0.910
CBL
E3 ubiquitin-protein ligase CBL.
    
 0.903
CBLB
Cbl proto-oncogene B.
    
 0.902
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.