STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HIPK1Homeodomain-interacting protein kinase 1 isoform X1. (915 aa)    
Predicted Functional Partners:
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.949
RASSF5
Ras association domain-containing protein 5.
    
  0.885
HIPK3
Homeodomain-interacting protein kinase 3 isoform X1.
   
 
 
0.876
RITA1
RBPJ-interacting and tubulin-associated protein 1.
      
 0.841
ENSEEUP00000013950
annotation not available
  
  
 
0.825
HIPK4
Homeodomain-interacting protein kinase 4.
     
0.822
ENSEEUP00000005938
annotation not available
    
 0.677
SUMO1
Small ubiquitin-related modifier.
    
 0.653
RUNX2
Runt-related transcription factor 2 isoform X2.
    
  0.639
CBFB
Core-binding factor subunit beta isoform X1.
     
 0.612
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.