STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SMYD5SET and MYND domain-containing protein 5. (342 aa)    
Predicted Functional Partners:
SMYD4
SET and MYND domain-containing protein 4.
      
 0.869
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
   
 0.814
PRDM4
PR domain zinc finger protein 4; May function as a transcription factor involved in cell differentiation.
   
 0.762
EED
Polycomb protein EED isoform X2.
    
 0.748
ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase isoform X1.
 
 
    0.747
ASH2L
set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X3.
    
 0.744
RBBP5
Retinoblastoma-binding protein 5.
    
 0.743
ENSEEUP00000010595
annotation not available
    
 0.742
MPHOSPH8
M-phase phosphoprotein 8 isoform X2.
    
 0.731
KMT2E
Histone-lysine N-methyltransferase 2E.
    
 0.726
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.