STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RPS19BP1Active regulator of SIRT1. (136 aa)    
Predicted Functional Partners:
SIRT1
NAD-dependent protein deacetylase sirtuin-1.
    
 0.781
WDR46
WD repeat-containing protein 46 isoform X1.
   
 
 0.746
MPHOSPH10
U3 small nucleolar ribonucleoprotein protein MPP10; Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing; Belongs to the MPP10 family.
    
 
 0.683
SIRT5
NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Modulates ketogenesis through the desuccinyl [...]
    
 0.670
EMG1
Ribosomal RNA small subunit methyltransferase NEP1 isoform X1.
   
   0.637
RPS19
40S ribosomal protein S19 isoform X2.
    
 
 0.628
SIRT3
NAD-dependent protein deacetylase; NAD-dependent protein deacetylase.
    
 0.617
RRP7A
Ribosomal RNA-processing protein 7 homolog A.
   
   0.601
RPS23
40S ribosomal protein S23; Belongs to the universal ribosomal protein uS12 family.
   
 
 0.598
LOC103112511
LOW QUALITY PROTEIN: 40S ribosomal protein S23-like; Belongs to the universal ribosomal protein uS12 family.
   
 
 0.598
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.