STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NUAK2NUAK family SNF1-like kinase 2. (631 aa)    
Predicted Functional Partners:
BRSK2
Serine/threonine-protein kinase BRSK2.
 
 
  
0.812
MED20
Mediator of RNA polymerase II transcription subunit 20; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
      
 0.692
ARHGEF17
Rho guanine nucleotide exchange factor 17.
      
 0.674
ARHGAP28
Rho GTPase activating protein 28.
   
  
 0.638
DOCK5
Dedicator of cytokinesis protein 5; Belongs to the DOCK family.
    
 
 0.606
ENSEEUP00000011381
annotation not available
      
 0.573
PRKAA1
Protein kinase AMP-activated catalytic subunit alpha 1.
  
 
0.559
AMOTL2
Angiomotin-like protein 2.
   
  
 0.557
MELK
Non-specific serine/threonine protein kinase.
  
 
0.511
NIM1K
Serine/threonine-protein kinase NIM1; Belongs to the protein kinase superfamily.
  
 
0.505
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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