STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC2A2Solute carrier family 2, facilitated glucose transporter member 2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (528 aa)    
Predicted Functional Partners:
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.876
ENSEEUP00000000135
annotation not available
   
  
 0.782
GCK
Glucokinase.
   
  
 0.771
GAPDH
Glyceraldehyde-3-phosphate dehydrogenase.
   
 0.759
SLC2A4
Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.
  
  
 
0.691
CYB5R4
Cytochrome b5 reductase 4.
   
  0.664
ABCC8
ATP-binding cassette sub-family C member 8 isoform X1.
   
 
 0.646
SLC30A8
Zinc transporter 8.
    
 0.642
EPHX2
Bifunctional epoxide hydrolase 2 isoform X1.
  
 
 0.619
ENSEEUP00000005049
annotation not available
   
 
 0.617
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.