SPIC protein (Erinaceus europaeus) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

SPIC

Transcription factor Spi-C. (180 aa)

Predicted Functional Partners:

RUNX2

0.704

ENSEEUP00000005100

0.655

NR1H3

0.642

HPX

0.642

GTSF1

0.530

C5orf30

0.491

ANO4

0.483

DDIT3

0.479

CEBPE

0.479

HLF

0.479

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANO4	SPIC	ENSEEUP00000008281	ENSEEUP00000011351	Anoctamin.	Transcription factor Spi-C.	0.483
C5orf30	SPIC	ENSEEUP00000002600	ENSEEUP00000011351	UNC119-binding protein C5orf30 homolog.	Transcription factor Spi-C.	0.491
CEBPE	DDIT3	ENSEEUP00000005301	ENSEEUP00000003288	CCAAT/enhancer-binding protein.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.728
CEBPE	RUNX2	ENSEEUP00000005301	ENSEEUP00000008426	CCAAT/enhancer-binding protein.	Runt-related transcription factor 2 isoform X2.	0.854
CEBPE	SPIC	ENSEEUP00000005301	ENSEEUP00000011351	CCAAT/enhancer-binding protein.	Transcription factor Spi-C.	0.479
DDIT3	CEBPE	ENSEEUP00000003288	ENSEEUP00000005301	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	CCAAT/enhancer-binding protein.	0.728
DDIT3	RUNX2	ENSEEUP00000003288	ENSEEUP00000008426	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Runt-related transcription factor 2 isoform X2.	0.773
DDIT3	SPIC	ENSEEUP00000003288	ENSEEUP00000011351	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	Transcription factor Spi-C.	0.479
ENSEEUP00000005100	SPIC	ENSEEUP00000005100	ENSEEUP00000011351	annotation not available	Transcription factor Spi-C.	0.655
GTSF1	SPIC	ENSEEUP00000004716	ENSEEUP00000011351	Gametocyte-specific factor 1.	Transcription factor Spi-C.	0.530
HLF	RUNX2	ENSEEUP00000009978	ENSEEUP00000008426	Hepatic leukemia factor isoform X2.	Runt-related transcription factor 2 isoform X2.	0.780
HLF	SPIC	ENSEEUP00000009978	ENSEEUP00000011351	Hepatic leukemia factor isoform X2.	Transcription factor Spi-C.	0.479
HPX	SPIC	ENSEEUP00000013073	ENSEEUP00000011351	Hemopexin.	Transcription factor Spi-C.	0.642
NR1H3	RUNX2	ENSEEUP00000003000	ENSEEUP00000008426	Oxysterols receptor LXR-alpha isoform X2.	Runt-related transcription factor 2 isoform X2.	0.481
NR1H3	SPIC	ENSEEUP00000003000	ENSEEUP00000011351	Oxysterols receptor LXR-alpha isoform X2.	Transcription factor Spi-C.	0.642
RUNX2	CEBPE	ENSEEUP00000008426	ENSEEUP00000005301	Runt-related transcription factor 2 isoform X2.	CCAAT/enhancer-binding protein.	0.854
RUNX2	DDIT3	ENSEEUP00000008426	ENSEEUP00000003288	Runt-related transcription factor 2 isoform X2.	DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...]	0.773
RUNX2	HLF	ENSEEUP00000008426	ENSEEUP00000009978	Runt-related transcription factor 2 isoform X2.	Hepatic leukemia factor isoform X2.	0.780
RUNX2	NR1H3	ENSEEUP00000008426	ENSEEUP00000003000	Runt-related transcription factor 2 isoform X2.	Oxysterols receptor LXR-alpha isoform X2.	0.481
RUNX2	SPIC	ENSEEUP00000008426	ENSEEUP00000011351	Runt-related transcription factor 2 isoform X2.	Transcription factor Spi-C.	0.704