GPR39 protein (Erinaceus europaeus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GPR39

G-protein coupled receptor 39; Belongs to the G-protein coupled receptor 1 family. (319 aa)

Predicted Functional Partners:

GRK2

0.693

GNA14

0.690

NTS

0.686

GNAQ

0.684

GHRL

0.676

ENSEEUP00000003756

0.641

ENSEEUP00000005619

0.622

PLCB1

0.616

BTK

0.616

ENSEEUP00000007888

0.577

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTK	GNA14	ENSEEUP00000014292	ENSEEUP00000004283	Tyrosine-protein kinase.	Guanine nucleotide-binding protein subunit alpha-14.	0.670
BTK	GNAQ	ENSEEUP00000014292	ENSEEUP00000011042	Tyrosine-protein kinase.	Guanine nucleotide-binding protein G(Q) subunit alpha.	0.665
BTK	GPR39	ENSEEUP00000014292	ENSEEUP00000013195	Tyrosine-protein kinase.	G-protein coupled receptor 39; Belongs to the G-protein coupled receptor 1 family.	0.616
BTK	NTS	ENSEEUP00000014292	ENSEEUP00000004746	Tyrosine-protein kinase.	Neurotensin/neuromedin N.	0.649
ENSEEUP00000003756	GHRL	ENSEEUP00000003756	ENSEEUP00000003411	annotation not available	Ghrelin and obestatin prepropeptide.	0.558
ENSEEUP00000003756	GNA14	ENSEEUP00000003756	ENSEEUP00000004283	annotation not available	Guanine nucleotide-binding protein subunit alpha-14.	0.825
ENSEEUP00000003756	GNAQ	ENSEEUP00000003756	ENSEEUP00000011042	annotation not available	Guanine nucleotide-binding protein G(Q) subunit alpha.	0.825
ENSEEUP00000003756	GPR39	ENSEEUP00000003756	ENSEEUP00000013195	annotation not available	G-protein coupled receptor 39; Belongs to the G-protein coupled receptor 1 family.	0.641
ENSEEUP00000003756	GRK2	ENSEEUP00000003756	ENSEEUP00000001931	annotation not available	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.865
ENSEEUP00000003756	NTS	ENSEEUP00000003756	ENSEEUP00000004746	annotation not available	Neurotensin/neuromedin N.	0.567
ENSEEUP00000005619	GPR39	ENSEEUP00000005619	ENSEEUP00000013195	annotation not available	G-protein coupled receptor 39; Belongs to the G-protein coupled receptor 1 family.	0.622
ENSEEUP00000007888	GHRL	ENSEEUP00000007888	ENSEEUP00000003411	annotation not available	Ghrelin and obestatin prepropeptide.	0.850
ENSEEUP00000007888	GPR39	ENSEEUP00000007888	ENSEEUP00000013195	annotation not available	G-protein coupled receptor 39; Belongs to the G-protein coupled receptor 1 family.	0.577
ENSEEUP00000007888	NTS	ENSEEUP00000007888	ENSEEUP00000004746	annotation not available	Neurotensin/neuromedin N.	0.824
GHRL	ENSEEUP00000003756	ENSEEUP00000003411	ENSEEUP00000003756	Ghrelin and obestatin prepropeptide.	annotation not available	0.558
GHRL	ENSEEUP00000007888	ENSEEUP00000003411	ENSEEUP00000007888	Ghrelin and obestatin prepropeptide.	annotation not available	0.850
GHRL	GNA14	ENSEEUP00000003411	ENSEEUP00000004283	Ghrelin and obestatin prepropeptide.	Guanine nucleotide-binding protein subunit alpha-14.	0.574
GHRL	GNAQ	ENSEEUP00000003411	ENSEEUP00000011042	Ghrelin and obestatin prepropeptide.	Guanine nucleotide-binding protein G(Q) subunit alpha.	0.566
GHRL	GPR39	ENSEEUP00000003411	ENSEEUP00000013195	Ghrelin and obestatin prepropeptide.	G-protein coupled receptor 39; Belongs to the G-protein coupled receptor 1 family.	0.676
GHRL	GRK2	ENSEEUP00000003411	ENSEEUP00000001931	Ghrelin and obestatin prepropeptide.	G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.	0.622