HEATR6 protein (Erinaceus europaeus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

HEATR6

HEAT repeat-containing protein 6. (1174 aa)

Predicted Functional Partners:

ENSEEUP00000001429

0.725

HEATR4

0.697

ENSEEUP00000004045

0.690

STK36

0.678

PLEKHA8

0.625

DHX40

0.599

BCAS3

0.557

MACF1

0.557

APPBP2

0.552

ENSEEUP00000010190

0.540

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APPBP2	BCAS3	ENSEEUP00000006074	ENSEEUP00000007372	Amyloid beta precursor protein binding protein 2.	Breast carcinoma-amplified sequence 3 isoform X1.	0.599
APPBP2	DHX40	ENSEEUP00000006074	ENSEEUP00000002318	Amyloid beta precursor protein binding protein 2.	Probable ATP-dependent RNA helicase DHX40 isoform X1.	0.593
APPBP2	ENSEEUP00000004045	ENSEEUP00000006074	ENSEEUP00000004045	Amyloid beta precursor protein binding protein 2.	annotation not available	0.430
APPBP2	ENSEEUP00000010190	ENSEEUP00000006074	ENSEEUP00000010190	Amyloid beta precursor protein binding protein 2.	annotation not available	0.665
APPBP2	HEATR6	ENSEEUP00000006074	ENSEEUP00000013228	Amyloid beta precursor protein binding protein 2.	HEAT repeat-containing protein 6.	0.552
BCAS3	APPBP2	ENSEEUP00000007372	ENSEEUP00000006074	Breast carcinoma-amplified sequence 3 isoform X1.	Amyloid beta precursor protein binding protein 2.	0.599
BCAS3	DHX40	ENSEEUP00000007372	ENSEEUP00000002318	Breast carcinoma-amplified sequence 3 isoform X1.	Probable ATP-dependent RNA helicase DHX40 isoform X1.	0.504
BCAS3	HEATR6	ENSEEUP00000007372	ENSEEUP00000013228	Breast carcinoma-amplified sequence 3 isoform X1.	HEAT repeat-containing protein 6.	0.557
DHX40	APPBP2	ENSEEUP00000002318	ENSEEUP00000006074	Probable ATP-dependent RNA helicase DHX40 isoform X1.	Amyloid beta precursor protein binding protein 2.	0.593
DHX40	BCAS3	ENSEEUP00000002318	ENSEEUP00000007372	Probable ATP-dependent RNA helicase DHX40 isoform X1.	Breast carcinoma-amplified sequence 3 isoform X1.	0.504
DHX40	ENSEEUP00000010190	ENSEEUP00000002318	ENSEEUP00000010190	Probable ATP-dependent RNA helicase DHX40 isoform X1.	annotation not available	0.453
DHX40	HEATR6	ENSEEUP00000002318	ENSEEUP00000013228	Probable ATP-dependent RNA helicase DHX40 isoform X1.	HEAT repeat-containing protein 6.	0.599
ENSEEUP00000001429	HEATR6	ENSEEUP00000001429	ENSEEUP00000013228	annotation not available	HEAT repeat-containing protein 6.	0.725
ENSEEUP00000004045	APPBP2	ENSEEUP00000004045	ENSEEUP00000006074	annotation not available	Amyloid beta precursor protein binding protein 2.	0.430
ENSEEUP00000004045	ENSEEUP00000010190	ENSEEUP00000004045	ENSEEUP00000010190	annotation not available	annotation not available	0.997
ENSEEUP00000004045	HEATR4	ENSEEUP00000004045	ENSEEUP00000007089	annotation not available	HEAT repeat-containing protein 4.	0.692
ENSEEUP00000004045	HEATR6	ENSEEUP00000004045	ENSEEUP00000013228	annotation not available	HEAT repeat-containing protein 6.	0.690
ENSEEUP00000004045	MACF1	ENSEEUP00000004045	ENSEEUP00000011833	annotation not available	Microtubule-actin cross-linking factor 1.	0.495
ENSEEUP00000004045	STK36	ENSEEUP00000004045	ENSEEUP00000012290	annotation not available	Serine/threonine-protein kinase 36-like.	0.531
ENSEEUP00000010190	APPBP2	ENSEEUP00000010190	ENSEEUP00000006074	annotation not available	Amyloid beta precursor protein binding protein 2.	0.665

page 1 of 3

Network Stats

number of nodes:

3

number of edges:

2

average node degree:

1.33

avg. local clustering coefficient:

0.667

expected number of edges:

2

PPI enrichment p-value:

0.526

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

6 of 143

1.2

1.18

0.00017

GO:0050896

Response to stimulus

9 of 320

1.03

1.14

2.79e-06

GO:0050794

Regulation of cellular process

10 of 417

0.96

1.05

1.33e-06

GO:0000160

Phosphorelay signal transduction system

4 of 80

1.28

0.9

0.0058

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016772

Transferase activity, transferring phosphorus-containing groups

5 of 171

1.04

0.58

0.0315

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

8 of 731

0.62

0.43

0.0116

GO:0016020

Membrane

9 of 1060

0.51

0.36

0.0116

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2286

His Kinase A (phosphoacceptor) domain, and PAS-associated, C-terminal

11 of 30

2.14

7.51

1.73e-20

CL:2287

His Kinase A (phosphoacceptor) domain, and PAS fold

9 of 25

2.13

6.36

1.89e-16

CL:2288

PAS-associated, C-terminal, and His Kinase A (phosphoacceptor) domain

6 of 18

2.1

4.22

3.75e-10

CL:2308

His Kinase A (phosphoacceptor) domain

3 of 8

2.15

2.05

9.45e-05

CL:2289

PAS-associated, C-terminal

3 of 10

2.05

1.91

0.00016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

9 of 332

1.01

1.15

8.50e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045121

Membrane raft

2 of 4

2.28

1.06

0.0110

GOCC:0016020

Membrane

8 of 515

0.77

0.61

0.0016

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

9 of 62

1.74

3.97

4.21e-13

KW-0418

Kinase

10 of 88

1.63

3.66

7.67e-14

KW-0175

Coiled coil

7 of 416

0.8

0.65

0.0013

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR005467

Histidine kinase domain

10 of 38

2.0

5.76

2.20e-16

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

9 of 31

2.04

5.6

4.75e-15

IPR003594

Histidine kinase/HSP90-like ATPase

10 of 46

1.91

5.28

5.97e-16

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

8 of 27

2.05

5.1

3.22e-13

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

10 of 54

1.84

4.87

1.69e-15

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

9 of 32

2.03

5.73

9.57e-16

SM00387

Histidine kinase-like ATPases

10 of 52

1.86

5.1

2.83e-16

SM00448

cheY-homologous receiver domain

9 of 53

1.81

4.45

3.66e-14

SM00091

PAS domain

5 of 38

1.7

2.39

1.06e-06

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 30

1.58

1.27

0.0015

(more ...)

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