ENSEEUP00000013918 protein (Erinaceus europaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

ENSEEUP00000013918

annotation not available (303 aa)

Predicted Functional Partners:

PEX12

0.967

PEX13

0.961

PEX16

0.927

PEX14

0.892

ABCD3

0.870

PEX11B

0.866

CLDN10

0.837

ENSEEUP00000000734

0.835

PEX5

0.826

PEX11A

0.825

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD3	CLDN10	ENSEEUP00000003798	ENSEEUP00000011711	ATP-binding cassette sub-family D member 3 isoform X3.	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	0.654
ABCD3	ENSEEUP00000000734	ENSEEUP00000003798	ENSEEUP00000000734	ATP-binding cassette sub-family D member 3 isoform X3.	annotation not available	0.997
ABCD3	ENSEEUP00000013918	ENSEEUP00000003798	ENSEEUP00000013918	ATP-binding cassette sub-family D member 3 isoform X3.	annotation not available	0.870
ABCD3	PEX11A	ENSEEUP00000003798	ENSEEUP00000004801	ATP-binding cassette sub-family D member 3 isoform X3.	Peroxisomal membrane protein 11A isoform X1.	0.712
ABCD3	PEX11B	ENSEEUP00000003798	ENSEEUP00000004694	ATP-binding cassette sub-family D member 3 isoform X3.	Peroxisomal membrane protein 11B isoform X1.	0.712
ABCD3	PEX12	ENSEEUP00000003798	ENSEEUP00000010593	ATP-binding cassette sub-family D member 3 isoform X3.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.783
ABCD3	PEX13	ENSEEUP00000003798	ENSEEUP00000003058	ATP-binding cassette sub-family D member 3 isoform X3.	Peroxisome biogenesis factor 13.	0.803
ABCD3	PEX14	ENSEEUP00000003798	ENSEEUP00000010184	ATP-binding cassette sub-family D member 3 isoform X3.	Peroxisomal membrane protein PEX14.	0.792
ABCD3	PEX16	ENSEEUP00000003798	ENSEEUP00000000639	ATP-binding cassette sub-family D member 3 isoform X3.	Peroxisomal membrane protein PEX16.	0.795
ABCD3	PEX5	ENSEEUP00000003798	ENSEEUP00000012429	ATP-binding cassette sub-family D member 3 isoform X3.	Peroxisomal biogenesis factor 5 isoform X1.	0.438
CLDN10	ABCD3	ENSEEUP00000011711	ENSEEUP00000003798	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	ATP-binding cassette sub-family D member 3 isoform X3.	0.654
CLDN10	ENSEEUP00000000734	ENSEEUP00000011711	ENSEEUP00000000734	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	annotation not available	0.697
CLDN10	ENSEEUP00000013918	ENSEEUP00000011711	ENSEEUP00000013918	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	annotation not available	0.837
CLDN10	PEX11A	ENSEEUP00000011711	ENSEEUP00000004801	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Peroxisomal membrane protein 11A isoform X1.	0.774
CLDN10	PEX11B	ENSEEUP00000011711	ENSEEUP00000004694	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Peroxisomal membrane protein 11B isoform X1.	0.774
CLDN10	PEX12	ENSEEUP00000011711	ENSEEUP00000010593	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family.	0.808
CLDN10	PEX13	ENSEEUP00000011711	ENSEEUP00000003058	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Peroxisome biogenesis factor 13.	0.818
CLDN10	PEX14	ENSEEUP00000011711	ENSEEUP00000010184	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Peroxisomal membrane protein PEX14.	0.799
CLDN10	PEX16	ENSEEUP00000011711	ENSEEUP00000000639	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Peroxisomal membrane protein PEX16.	0.805
ENSEEUP00000000734	ABCD3	ENSEEUP00000000734	ENSEEUP00000003798	annotation not available	ATP-binding cassette sub-family D member 3 isoform X3.	0.997

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.926

expected number of edges:

12

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006006

Glucose metabolic process

6 of 12

2.19

3.99

3.96e-09

GO:0006096

Glycolytic process

5 of 8

2.29

3.67

4.16e-08

GO:0005975

Carbohydrate metabolic process

8 of 222

1.05

1.19

2.76e-06

GO:1901575

Organic substance catabolic process

6 of 137

1.14

1.16

7.46e-05

GO:0006094

Gluconeogenesis

2 of 6

2.02

1.13

0.0070

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016620

Oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

4 of 21

1.78

1.6

0.00040

GO:0050661

NADP binding

3 of 14

1.83

1.25

0.0031

GO:0051287

NAD binding

3 of 23

1.61

0.98

0.0089

GO:0016861

Intramolecular oxidoreductase activity, interconverting aldoses and ketoses

2 of 8

1.89

0.7

0.0483

GO:0003824

Catalytic activity

11 of 1707

0.3

0.23

0.0483

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 1047

0.48

0.36

0.0059

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:941

Pentose phosphate pathway, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

10 of 25

2.1

6.46

2.44e-17

CL:943

Glycolysis, and Glyceraldehyde/Erythrose phosphate dehydrogenase family

8 of 13

2.28

6.22

1.78e-14

CL:947

Glyceraldehyde 3-phosphate dehydrogenase, active site, and Glycolysis

5 of 5

2.5

4.32

3.77e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00010

Glycolysis / Gluconeogenesis

9 of 37

1.88

4.81

1.92e-14

map01200

Carbon metabolism

11 of 95

1.56

3.53

1.67e-15

map00030

Pentose phosphate pathway

5 of 24

1.81

2.7

3.99e-07

map01120

Microbial metabolism in diverse environments

11 of 248

1.14

1.7

1.42e-11

map01230

Biosynthesis of amino acids

7 of 123

1.25

1.61

6.54e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005737

Cytoplasm

9 of 849

0.52

0.33

0.0339

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

5 of 8

2.29

3.74

2.81e-08

KW-0312

Gluconeogenesis

2 of 4

2.19

1.01

0.0134

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02800

Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain

3 of 3

2.5

1.95

0.00024

PF01081

KDPG and KHG aldolase

2 of 2

2.5

1.02

0.0136

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020831

Glyceraldehyde/Erythrose phosphate dehydrogenase family

3 of 3

2.5

1.73

0.00062

IPR020829

Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain

3 of 3

2.5

1.73

0.00062

IPR020828

Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain

3 of 3

2.5

1.73

0.00062

IPR013785

Aldolase-type TIM barrel

4 of 48

1.42

1.01

0.0046

IPR020830

Glyceraldehyde 3-phosphate dehydrogenase, active site

2 of 2

2.5

1.01

0.0144

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00846

Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain

3 of 3

2.5

2.29

5.17e-05

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (28%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2024

Credits

Access

Info

About