LOC103121078-5 protein (Erinaceus europaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

LOC103121078-5

Histone H4. (103 aa)

Predicted Functional Partners:

H2BU1

0.997

H3F3A

0.975

H3-3A

0.975

H3F3A-2

0.975

ENSEEUP00000005780

0.972

ENSEEUP00000005030

0.966

LOC103113974

0.954

ENSEEUP00000012990

0.954

ENSEEUP00000005596

0.951

ENSEEUP00000004408

0.950

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSEEUP00000004408	ENSEEUP00000005030	ENSEEUP00000004408	ENSEEUP00000005030	annotation not available	annotation not available	0.995
ENSEEUP00000004408	ENSEEUP00000005596	ENSEEUP00000004408	ENSEEUP00000005596	annotation not available	annotation not available	0.844
ENSEEUP00000004408	ENSEEUP00000005780	ENSEEUP00000004408	ENSEEUP00000005780	annotation not available	annotation not available	0.803
ENSEEUP00000004408	ENSEEUP00000012990	ENSEEUP00000004408	ENSEEUP00000012990	annotation not available	annotation not available	0.700
ENSEEUP00000004408	H2BU1	ENSEEUP00000004408	ENSEEUP00000012925	annotation not available	Histone H2B; Belongs to the histone H2B family.	0.802
ENSEEUP00000004408	H3-3A	ENSEEUP00000004408	ENSEEUP00000012558	annotation not available	H3 histone, family 3A.	0.803
ENSEEUP00000004408	H3F3A	ENSEEUP00000004408	ENSEEUP00000002037	annotation not available	Histone H3; Belongs to the histone H3 family.	0.803
ENSEEUP00000004408	H3F3A-2	ENSEEUP00000004408	ENSEEUP00000014315	annotation not available	H3 histone, family 3A.	0.803
ENSEEUP00000004408	LOC103113974	ENSEEUP00000004408	ENSEEUP00000005084	annotation not available	Histone H2A; Belongs to the histone H2A family.	0.700
ENSEEUP00000004408	LOC103121078-5	ENSEEUP00000004408	ENSEEUP00000014407	annotation not available	Histone H4.	0.950
ENSEEUP00000005030	ENSEEUP00000004408	ENSEEUP00000005030	ENSEEUP00000004408	annotation not available	annotation not available	0.995
ENSEEUP00000005030	ENSEEUP00000005596	ENSEEUP00000005030	ENSEEUP00000005596	annotation not available	annotation not available	0.883
ENSEEUP00000005030	ENSEEUP00000005780	ENSEEUP00000005030	ENSEEUP00000005780	annotation not available	annotation not available	0.915
ENSEEUP00000005030	H3-3A	ENSEEUP00000005030	ENSEEUP00000012558	annotation not available	H3 histone, family 3A.	0.915
ENSEEUP00000005030	H3F3A	ENSEEUP00000005030	ENSEEUP00000002037	annotation not available	Histone H3; Belongs to the histone H3 family.	0.915
ENSEEUP00000005030	H3F3A-2	ENSEEUP00000005030	ENSEEUP00000014315	annotation not available	H3 histone, family 3A.	0.915
ENSEEUP00000005030	LOC103121078-5	ENSEEUP00000005030	ENSEEUP00000014407	annotation not available	Histone H4.	0.966
ENSEEUP00000005596	ENSEEUP00000004408	ENSEEUP00000005596	ENSEEUP00000004408	annotation not available	annotation not available	0.844
ENSEEUP00000005596	ENSEEUP00000005030	ENSEEUP00000005596	ENSEEUP00000005030	annotation not available	annotation not available	0.883
ENSEEUP00000005596	ENSEEUP00000005780	ENSEEUP00000005596	ENSEEUP00000005780	annotation not available	annotation not available	0.803

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

18

average node degree:

3.27

avg. local clustering coefficient:

0.813

expected number of edges:

10

PPI enrichment p-value:

0.0158

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016444

Somatic cell DNA recombination

3 of 3

3.31

3.17

1.89e-06

GO:0070131

Positive regulation of mitochondrial translation

3 of 6

3.01

3.05

2.79e-06

GO:0007004

Telomere maintenance via telomerase

3 of 11

2.74

2.81

6.39e-06

GO:0006310

DNA recombination

6 of 202

1.78

2.64

4.50e-07

GO:0051321

Meiotic cell cycle

5 of 129

1.9

2.58

1.89e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043047

Single-stranded telomeric DNA binding

3 of 7

2.94

2.8

7.85e-06

GO:0008408

3-5 exonuclease activity

4 of 41

2.3

2.65

6.90e-06

GO:0000175

3-5-exoribonuclease activity

3 of 17

2.56

2.47

2.48e-05

GO:0003684

Damaged DNA binding

3 of 31

2.29

2.15

7.78e-05

GO:0003676

Nucleic acid binding

9 of 2305

0.9

1.78e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005662

DNA replication factor A complex

3 of 4

3.18

3.09

2.48e-06

GO:0043596

Nuclear replication fork

4 of 44

2.27

2.85

2.48e-06

GO:0000781

Chromosome, telomeric region

3 of 46

2.12

1.98

0.00013

GO:0000794

Condensed nuclear chromosome

2 of 23

2.25

1.34

0.0031

GO:0005634

Nucleus

9 of 3364

0.74

0.65

0.00013

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12858

HDR through Single Strand Annealing (SSA), and DNA damage sensor activity

7 of 42

2.53

6.43

1.08e-13

CL:12864

HDR through Single Strand Annealing (SSA), and Checkpoint clamp complex

5 of 17

2.78

5.42

5.55e-11

CL:12865

Mixed, incl. Checkpoint clamp complex, and FATC domain

3 of 12

2.71

2.88

4.53e-06

CL:12888

RecQ family helicase-topoisomerase III complex, and DNA replication factor A complex

2 of 5

2.91

1.82

0.00050

CL:12929

Mixed, incl. DNA topological change, and RecQ mediated genome instability protein 1, N-terminal

2 of 6

2.83

1.76

0.00063

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03018

RNA degradation

4 of 132

1.79

1.92

6.09e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5685938

HDR through Single Strand Annealing (SSA)

7 of 42

2.53

6.86

1.16e-14

MAP-5693567

HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)

9 of 119

2.19

6.54

2.45e-16

MAP-5693538

Homology Directed Repair

9 of 131

2.15

6.36

2.81e-16

MAP-69473

G2/M DNA damage checkpoint

7 of 59

2.38

6.2

8.37e-14

MAP-6804756

Regulation of TP53 Activity through Phosphorylation

7 of 60

2.38

6.18

8.37e-14

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0043596

Nuclear replication fork

5 of 28

2.56

4.48

2.24e-09

GOCC:0005662

DNA replication factor A complex

3 of 5

3.09

3.19

1.59e-06

GOCC:0031298

Replication fork protection complex

2 of 3

3.13

2.06

0.00019

GOCC:0043227

Membrane-bounded organelle

11 of 4151

0.73

0.71

2.17e-06

GOCC:0043231

Intracellular membrane-bounded organelle

10 of 3677

0.74

0.69

2.17e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16900

Replication protein A OB domain

2 of 2

3.31

1.6

0.0013

PF04057

Replication factor-A protein 1, N-terminal domain

2 of 2

3.31

1.6

0.0013

PF01336

OB-fold nucleic acid binding domain

2 of 8

2.71

1.36

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR002562

3-5 exonuclease domain

3 of 6

3.01

2.57

2.11e-05

IPR031657

Replication protein A, OB domain

2 of 2

3.31

1.51

0.0019

IPR007199

Replication factor-A protein 1, N-terminal

2 of 2

3.31

1.51

0.0019

IPR004365

OB-fold nucleic acid binding domain, AA-tRNA synthetase-type

2 of 8

2.71

1.19

0.0070

IPR012337

Ribonuclease H-like superfamily

3 of 108

1.75

0.99

0.0108

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00474

3-5 exonuclease

2 of 3

3.13

1.75

0.00069

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (22%) [HD]

Permalink

Network

Fusion

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Neighborhood

© STRING Consortium 2024

Credits

Access

Info

About