STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BACE2Beta-secretase 2. (300 aa)    
Predicted Functional Partners:
RTN3
Reticulon 3.
   
 0.947
ENSETEP00000008428
annotation not available
   
 0.945
GGA2
Golgi associated, gamma adaptin ear containing, ARF binding protein 2.
    
 0.903
BACE1
Beta-secretase 1.
  
  
 
0.892
APP
Amyloid beta precursor protein.
    
 0.882
RTN2
Reticulon 2.
   
 0.762
APLP2
Amyloid beta precursor like protein 2.
    
 0.760
ENSETEP00000007877
annotation not available
   
 0.752
NCSTN
Nicastrin.
    
 
 0.675
ENSETEP00000013367
annotation not available
   
 0.652
Your Current Organism:
Echinops telfairi
NCBI taxonomy Id: 9371
Other names: E. telfairi, Echinops telfairii, lesser hedgehog tenrec, small Madagascar hedgehog
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.