node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SMC52203.1 | SMC82567.1 | SAMN06297251_103150 | SAMN06297251_10989 | Porphobilinogen synthase; Belongs to the ALAD family. | Precorrin-2/cobalt-factor-2 C20-methyltransferase. | 0.458 |
SMC52203.1 | SMC96648.1 | SAMN06297251_103150 | SAMN06297251_11515 | Porphobilinogen synthase; Belongs to the ALAD family. | Amino acid adenylation domain-containing protein. | 0.922 |
SMC52203.1 | SMC96661.1 | SAMN06297251_103150 | SAMN06297251_11517 | Porphobilinogen synthase; Belongs to the ALAD family. | Acyl carrier protein. | 0.922 |
SMC52203.1 | SMD00570.1 | SAMN06297251_103150 | SAMN06297251_117100 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.971 |
SMC52203.1 | SMD08620.1 | SAMN06297251_103150 | SAMN06297251_12510 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.966 |
SMC52203.1 | hemC | SAMN06297251_103150 | SAMN06297251_12511 | Porphobilinogen synthase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.995 |
SMC52203.1 | hemE | SAMN06297251_103150 | SAMN06297251_12764 | Porphobilinogen synthase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.765 |
SMC82567.1 | SMC52203.1 | SAMN06297251_10989 | SAMN06297251_103150 | Precorrin-2/cobalt-factor-2 C20-methyltransferase. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.458 |
SMC82567.1 | SMC96648.1 | SAMN06297251_10989 | SAMN06297251_11515 | Precorrin-2/cobalt-factor-2 C20-methyltransferase. | Amino acid adenylation domain-containing protein. | 0.570 |
SMC82567.1 | SMC96661.1 | SAMN06297251_10989 | SAMN06297251_11517 | Precorrin-2/cobalt-factor-2 C20-methyltransferase. | Acyl carrier protein. | 0.534 |
SMC82567.1 | SMD00570.1 | SAMN06297251_10989 | SAMN06297251_117100 | Precorrin-2/cobalt-factor-2 C20-methyltransferase. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.949 |
SMC82567.1 | SMD08620.1 | SAMN06297251_10989 | SAMN06297251_12510 | Precorrin-2/cobalt-factor-2 C20-methyltransferase. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.679 |
SMC82567.1 | hemC | SAMN06297251_10989 | SAMN06297251_12511 | Precorrin-2/cobalt-factor-2 C20-methyltransferase. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.781 |
SMC96648.1 | SMC52203.1 | SAMN06297251_11515 | SAMN06297251_103150 | Amino acid adenylation domain-containing protein. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.922 |
SMC96648.1 | SMC82567.1 | SAMN06297251_11515 | SAMN06297251_10989 | Amino acid adenylation domain-containing protein. | Precorrin-2/cobalt-factor-2 C20-methyltransferase. | 0.570 |
SMC96648.1 | SMC96661.1 | SAMN06297251_11515 | SAMN06297251_11517 | Amino acid adenylation domain-containing protein. | Acyl carrier protein. | 0.999 |
SMC96648.1 | SMD00570.1 | SAMN06297251_11515 | SAMN06297251_117100 | Amino acid adenylation domain-containing protein. | uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. | 0.835 |
SMC96648.1 | SMD08620.1 | SAMN06297251_11515 | SAMN06297251_12510 | Amino acid adenylation domain-containing protein. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.757 |
SMC96648.1 | hemC | SAMN06297251_11515 | SAMN06297251_12511 | Amino acid adenylation domain-containing protein. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.805 |
SMC96648.1 | hemE | SAMN06297251_11515 | SAMN06297251_12764 | Amino acid adenylation domain-containing protein. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.593 |