STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha. (792 aa)    
Predicted Functional Partners:
PPARG
Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]
   
 0.999
SIRT1
NAD-dependent deacetylase sirtuin-1.
   
 0.989
NRF1
Nuclear respiratory factor 1.
   
 0.989
ESRRA
Steroid hormone receptor ERR1.
   
 0.983
PPARA
Peroxisome proliferator-activated receptor alpha.
   
 0.981
FOXO1
Forkhead box protein O1.
    
 0.981
TFAM
Transcription factor A, mitochondrial.
     
 0.974
CREB1
Cyclic AMP-responsive element-binding protein 1.
   
 
 0.970
SOD2
Superoxide dismutase [Mn], mitochondrial.
     
 0.952
GPX7
Glutathione peroxidase; Belongs to the glutathione peroxidase family.
     
 0.942
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.