STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2582 aa)    
Predicted Functional Partners:
ADNP
Activity-dependent neuroprotector homeobox protein.
   
 
 0.812
BRD4
Bromodomain-containing protein 4.
   
 
 0.800
CHD6
Chromodomain-helicase-DNA-binding protein 6.
 
 
  
0.739
TOX4
TOX high mobility group box family member 4.
    
 0.694
SUPT16H
FACT complex subunit SPT16.
   
 
 0.684
EP300
Histone acetyltransferase p300.
   
 0.670
RBBP5
Retinoblastoma-binding protein 5.
   
 
 0.647
SETD5
SET domain-containing protein 5.
   
 0.647
WDR5
WD repeat-containing protein 5.
    
 0.595
HMG20A
High mobility group protein 20A.
    
 0.594
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.