STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GHRLAppetite-regulating hormone. (116 aa)    
Predicted Functional Partners:
GHSR
Growth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family.
    
 0.999
L5KPB4_PTEAL
Somatotropin.
   
 
 0.972
LEP
Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]
     
 0.967
L5KR12_PTEAL
Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
     
 0.959
GCG
Seprase; Belongs to the peptidase S9B family.
   
 
 0.957
POMC
Pro-opiomelanocortin.
      
 0.914
PCSK1
Neuroendocrine convertase 1; Belongs to the peptidase S8 family.
     
 0.893
AGRP
Agouti-related protein.
   
  
 0.869
CCK
Cholecystokinin.
     
 0.819
DRD2
D(2) dopamine receptor; Belongs to the G-protein coupled receptor 1 family.
   
 0.815
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.