node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AMH | ESR1 | L5L6S3 | L5KFQ3 | Muellerian-inhibiting factor. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.452 |
AMH | FSHB | L5L6S3 | L5KYY5 | Muellerian-inhibiting factor. | Follitropin subunit beta. | 0.496 |
AMH | FSHR | L5L6S3 | L5KTB5 | Muellerian-inhibiting factor. | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | 0.856 |
AMH | L5KCR2_PTEAL | L5L6S3 | L5KCR2 | Muellerian-inhibiting factor. | Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. | 0.720 |
AMH | LEP | L5L6S3 | L5KRQ0 | Muellerian-inhibiting factor. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.502 |
ESR1 | AMH | L5KFQ3 | L5L6S3 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Muellerian-inhibiting factor. | 0.452 |
ESR1 | FSHB | L5KFQ3 | L5KYY5 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Follitropin subunit beta. | 0.452 |
ESR1 | FSHR | L5KFQ3 | L5KTB5 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | 0.719 |
ESR1 | KISS1R | L5KFQ3 | L5L779 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | KiSS-1 receptor. | 0.720 |
ESR1 | L5JXV2_PTEAL | L5KFQ3 | L5JXV2 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Metastasis-suppressor KiSS-1. | 0.604 |
ESR1 | L5KCR2_PTEAL | L5KFQ3 | L5KCR2 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. | 0.749 |
ESR1 | LEP | L5KFQ3 | L5KRQ0 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.750 |
ESR1 | NPVF | L5KFQ3 | L5KLR2 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | FMRFamide-related peptide. | 0.561 |
ESR1 | NPY | L5KFQ3 | L5KPL5 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Neuropeptide Y. | 0.618 |
ESR1 | POMC | L5KFQ3 | L5KRG1 | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | Pro-opiomelanocortin. | 0.493 |
FSHB | AMH | L5KYY5 | L5L6S3 | Follitropin subunit beta. | Muellerian-inhibiting factor. | 0.496 |
FSHB | ESR1 | L5KYY5 | L5KFQ3 | Follitropin subunit beta. | Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. | 0.452 |
FSHB | FSHR | L5KYY5 | L5KTB5 | Follitropin subunit beta. | Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. | 0.975 |
FSHB | KISS1R | L5KYY5 | L5L779 | Follitropin subunit beta. | KiSS-1 receptor. | 0.455 |
FSHB | L5KCR2_PTEAL | L5KYY5 | L5KCR2 | Follitropin subunit beta. | Gonadoliberin; Stimulates the secretion of gonadotropins. Belongs to the GnRH family. | 0.744 |