EML4 protein (Pteropus alecto) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EML4

Echinoderm microtubule-associated protein-like 4. (980 aa)

Predicted Functional Partners:

ALK

0.962

PIK3CA

0.942

NRAS

0.923

HRAS

0.923

PLCG1

0.915

PIK3R1

0.913

JAK3

0.910

JAK1

0.907

PLCG2

0.905

L5K6I9_PTEAL

0.903

Your Current Organism:

Pteropus alecto

NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALK	EML4	L5KRL4	L5KVA3	ALK tyrosine kinase receptor.	Echinoderm microtubule-associated protein-like 4.	0.962
ALK	HRAS	L5KRL4	L5KN77	ALK tyrosine kinase receptor.	GTPase HRas.	0.938
ALK	JAK1	L5KRL4	L5K6W6	ALK tyrosine kinase receptor.	Tyrosine-protein kinase.	0.935
ALK	JAK3	L5KRL4	L5L7Y5	ALK tyrosine kinase receptor.	Tyrosine-protein kinase.	0.935
ALK	L5K6I9_PTEAL	L5KRL4	L5K6I9	ALK tyrosine kinase receptor.	Phosphatidylinositol 3-kinase regulatory subunit gamma.	0.929
ALK	NRAS	L5KRL4	L5K2M8	ALK tyrosine kinase receptor.	GTPase NRas.	0.938
ALK	PIK3CA	L5KRL4	L5KPB2	ALK tyrosine kinase receptor.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.960
ALK	PIK3R1	L5KRL4	L5KLH8	ALK tyrosine kinase receptor.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.933
ALK	PLCG1	L5KRL4	L5JYN7	ALK tyrosine kinase receptor.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.940
ALK	PLCG2	L5KRL4	L5KTA0	ALK tyrosine kinase receptor.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.937
EML4	ALK	L5KVA3	L5KRL4	Echinoderm microtubule-associated protein-like 4.	ALK tyrosine kinase receptor.	0.962
EML4	HRAS	L5KVA3	L5KN77	Echinoderm microtubule-associated protein-like 4.	GTPase HRas.	0.923
EML4	JAK1	L5KVA3	L5K6W6	Echinoderm microtubule-associated protein-like 4.	Tyrosine-protein kinase.	0.907
EML4	JAK3	L5KVA3	L5L7Y5	Echinoderm microtubule-associated protein-like 4.	Tyrosine-protein kinase.	0.910
EML4	L5K6I9_PTEAL	L5KVA3	L5K6I9	Echinoderm microtubule-associated protein-like 4.	Phosphatidylinositol 3-kinase regulatory subunit gamma.	0.903
EML4	NRAS	L5KVA3	L5K2M8	Echinoderm microtubule-associated protein-like 4.	GTPase NRas.	0.923
EML4	PIK3CA	L5KVA3	L5KPB2	Echinoderm microtubule-associated protein-like 4.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.942
EML4	PIK3R1	L5KVA3	L5KLH8	Echinoderm microtubule-associated protein-like 4.	Phosphatidylinositol 3-kinase regulatory subunit alpha.	0.913
EML4	PLCG1	L5KVA3	L5JYN7	Echinoderm microtubule-associated protein-like 4.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.915
EML4	PLCG2	L5KVA3	L5KTA0	Echinoderm microtubule-associated protein-like 4.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.905