STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IRF3Interferon regulatory factor 3. (420 aa)    
Predicted Functional Partners:
TBK1
Serine/threonine-protein kinase TBK1.
   
 0.999
EP300
Histone acetyltransferase p300.
    
 0.993
L5KGL1_PTEAL
CREB-binding protein.
    
 0.990
TICAM1
TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.
    
 0.984
ISG15
Ubiquitin cross-reactive protein.
   
 0.983
IFNB1
Interferon beta.
     
 0.982
PIN1
Peptidyl-prolyl cis-trans isomerase.
   
 0.980
IKBKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon.
   
 0.978
L5KN80_PTEAL
Interferon regulatory factor 7.
   
0.971
TMEM173
Transmembrane protein 173.
    
 0.950
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.