STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DET1DET1 like protein. (558 aa)    
Predicted Functional Partners:
DDB2
DNA damage-binding protein 2.
     
 0.935
DDB1
DNA damage-binding protein 1.
    
 
 0.917
ERCC8
DNA excision repair protein ERCC-8.
     
  0.900
CUL4B
Cullin-4B; Belongs to the cullin family.
    
 
 0.836
CUL4A
Cullin-4A; Belongs to the cullin family.
    
 
 0.805
L5KZK1_PTEAL
E3 ubiquitin-protein ligase RFWD2.
    
 
 0.798
ATXN7L3
Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...]
      
 0.729
DDA1
DET1-and DDB1-associated protein 1.
    
 
 0.659
ETV5
ETS translocation variant 5.
    
 
 0.575
L5KAJ1_PTEAL
Tribbles like protein 1.
    
 
 0.573
Your Current Organism:
Pteropus alecto
NCBI taxonomy Id: 9402
Other names: P. alecto, black flying fox
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.