node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABK46603.1 | ABK46671.1 | Shewana3_0360 | Shewana3_0428 | PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: son:SO0426 pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase. | 0.903 |
ABK46603.1 | gcvH | Shewana3_0360 | Shewana3_3500 | PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.917 |
ABK46603.1 | gcvP | Shewana3_0360 | Shewana3_3499 | PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.937 |
ABK46603.1 | gcvT | Shewana3_0360 | Shewana3_3501 | PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.939 |
ABK46603.1 | glyA | Shewana3_0360 | Shewana3_1094 | PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.939 |
ABK46671.1 | ABK46603.1 | Shewana3_0428 | Shewana3_0360 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: son:SO0426 pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase. | PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. | 0.903 |
ABK46671.1 | gcvH | Shewana3_0428 | Shewana3_3500 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: son:SO0426 pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.980 |
ABK46671.1 | gcvP | Shewana3_0428 | Shewana3_3499 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: son:SO0426 pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.955 |
ABK46671.1 | gcvT | Shewana3_0428 | Shewana3_3501 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: son:SO0426 pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.961 |
ABK46671.1 | glyA | Shewana3_0428 | Shewana3_1094 | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: son:SO0426 pyruvate dehydrogenase complex, E3 component, lipoamide dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.924 |
ABK49506.1 | ABK49834.1 | Shewana3_3282 | Shewana3_3612 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: son:SO4054 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.998 |
ABK49506.1 | fhs | Shewana3_3282 | Shewana3_0560 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: son:SO0560 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.955 |
ABK49506.1 | folD | Shewana3_3282 | Shewana3_2663 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.582 |
ABK49506.1 | gcvH | Shewana3_3282 | Shewana3_3500 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.730 |
ABK49506.1 | gcvP | Shewana3_3282 | Shewana3_3499 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.641 |
ABK49506.1 | gcvT | Shewana3_3282 | Shewana3_3501 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.958 |
ABK49506.1 | glyA | Shewana3_3282 | Shewana3_1094 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.947 |
ABK49506.1 | purH | Shewana3_3282 | Shewana3_0441 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | TIGRFAM: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme; MGS domain protein; KEGG: son:SO0442 phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.910 |
ABK49834.1 | ABK49506.1 | Shewana3_3612 | Shewana3_3282 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: son:SO4054 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.998 |
ABK49834.1 | fhs | Shewana3_3612 | Shewana3_0560 | TIGRFAM: 5,10-methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; KEGG: son:SO4054 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | PFAM: formate-tetrahydrofolate ligase, FTHFS; KEGG: son:SO0560 formate--tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.447 |