A0A2Z6Q8B1 protein (Rhizophagus clarus) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

A0A2Z6Q8B1

SET domain-containing protein. (162 aa)

Predicted Functional Partners:

A0A2Z6RA42

0.733

A0A2Z6RDX5

0.719

A0A2Z6QW26

0.718

A0A2Z6RSI4

0.708

A0A2Z6RIH2

0.692

A0A2Z6RX88

0.684

A0A2Z6RYT9

0.672

A0A2Z6R029

0.638

A0A2Z6QPB6

0.618

A0A2Z6QXU3

0.606

Your Current Organism:

Rhizophagus clarus

NCBI taxonomy Id: 94130
Other names: Glomus clarum, R. clarus, Rhizoglomus clarum, Rhizophagus clarus (T.H. Nicolson & N.C. Schenck) C. Walker & A. Schuessler 2010

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2Z6Q8B1	A0A2Z6QPB6	SET domain-containing protein.	Uncharacterized protein.	0.618
A0A2Z6Q8B1	A0A2Z6QW26	SET domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.718
A0A2Z6Q8B1	A0A2Z6QXU3	SET domain-containing protein.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.606
A0A2Z6Q8B1	A0A2Z6R029	SET domain-containing protein.	Metallophos domain-containing protein.	0.638
A0A2Z6Q8B1	A0A2Z6RA42	SET domain-containing protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.733
A0A2Z6Q8B1	A0A2Z6RDX5	SET domain-containing protein.	B30.2/SPRY domain-containing protein.	0.719
A0A2Z6Q8B1	A0A2Z6RIH2	SET domain-containing protein.	SET domain-containing protein.	0.692
A0A2Z6Q8B1	A0A2Z6RSI4	SET domain-containing protein.	Uncharacterized protein.	0.708
A0A2Z6Q8B1	A0A2Z6RX88	SET domain-containing protein.	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.684
A0A2Z6Q8B1	A0A2Z6RYT9	SET domain-containing protein.	VEFS-Box domain-containing protein.	0.672
A0A2Z6QPB6	A0A2Z6Q8B1	Uncharacterized protein.	SET domain-containing protein.	0.618
A0A2Z6QPB6	A0A2Z6QW26	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.773
A0A2Z6QPB6	A0A2Z6QXU3	Uncharacterized protein.	Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.	0.862
A0A2Z6QPB6	A0A2Z6R029	Uncharacterized protein.	Metallophos domain-containing protein.	0.823
A0A2Z6QPB6	A0A2Z6RA42	Uncharacterized protein.	Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.	0.963
A0A2Z6QPB6	A0A2Z6RDX5	Uncharacterized protein.	B30.2/SPRY domain-containing protein.	0.726
A0A2Z6QPB6	A0A2Z6RIH2	Uncharacterized protein.	SET domain-containing protein.	0.846
A0A2Z6QPB6	A0A2Z6RSI4	Uncharacterized protein.	Uncharacterized protein.	0.966
A0A2Z6QPB6	A0A2Z6RX88	Uncharacterized protein.	Histone-lysine N-methyltransferase, H3 lysine-79 specific.	0.920
A0A2Z6QPB6	A0A2Z6RYT9	Uncharacterized protein.	VEFS-Box domain-containing protein.	0.712

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.563

expected number of edges:

15

PPI enrichment p-value:

0.000234

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043966

Histone H3 acetylation

6 of 28

2.93

6.6

4.00e-13

GO:0006366

Transcription by RNA polymerase II

4 of 200

1.9

2.01

5.73e-05

GO:0051123

RNA polymerase II preinitiation complex assembly

2 of 22

2.56

1.44

0.0023

GO:0007369

Gastrulation

2 of 38

2.32

1.19

0.0062

GO:0006357

Regulation of transcription by RNA polymerase II

6 of 1917

1.09

0.98

0.00054

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003712

Transcription coregulator activity

8 of 523

1.78

3.55

1.97e-10

GO:0003713

Transcription coactivator activity

6 of 241

1.99

3.43

1.87e-08

GO:0017025

TBP-class protein binding

2 of 19

2.62

1.15

0.0080

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000124

SAGA complex

11 of 28

3.19

16.31

7.22e-32

GO:0046695

SLIK (SAGA-like) complex

2 of 6

3.12

2.21

0.00010

GO:0005669

Transcription factor TFIID complex

2 of 42

2.27

1.36

0.0029

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26339

SAGA-type complex, and Protein K6-linked deubiquitination

9 of 50

2.85

10.47

2.89e-21

CL:26345

Mixed, incl. SAGA complex, and SCA7 domain

8 of 32

2.99

10.16

4.27e-20

CL:26346

SAGA-type complex, and Tra1, HEAT repeat ring region

7 of 26

3.03

9.13

5.95e-18

CL:26350

SAGA complex, and PCAF, N-terminal

4 of 11

3.16

5.02

6.67e-10

CL:26377

SAGA complex, and PCAF, N-terminal

3 of 10

3.07

3.37

7.34e-07

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-3214847

HATs acetylate histones

5 of 99

2.3

3.67

4.31e-08

MAP-4839726

Chromatin organization

5 of 393

1.7

2.02

1.84e-05

MAP-3247509

Chromatin modifying enzymes

5 of 393

1.7

2.02

1.84e-05

MAP-5689880

Ub-specific processing proteases

3 of 424

1.45

0.64

0.0486

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070461

SAGA-type complex

10 of 37

3.03

13.4

1.19e-26

GOCC:0000124

SAGA complex

8 of 21

3.18

11.31

6.19e-22

GOCC:0031981

Nuclear lumen

11 of 1619

1.43

2.84

3.94e-14

GOCC:0046695

SLIK (SAGA-like) complex

2 of 4

3.3

2.31

6.71e-05

GOCC:0016591

RNA polymerase II, holoenzyme

2 of 114

1.84

0.83

0.0252

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10198

Histone acetyltransferases subunit 3

3 of 3

3.6

3.4

7.58e-07

PF03847

Transcription initiation factor TFIID subunit A

2 of 2

3.6

1.81

0.00055

PF02269

Transcription initiation factor IID, 18kD subunit

2 of 4

3.3

1.69

0.00092

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019340

Histone acetyltransferases subunit 3

3 of 3

3.6

3.16

2.09e-06

IPR037794

Transcription initiation factor TFIID subunit 12

2 of 2

3.6

1.57

0.0015

IPR003228

Transcription initiation factor TFIID subunit 12 domain

2 of 2

3.6

1.57

0.0015

IPR003195

Transcription initiation factor IID, subunit 13

2 of 4

3.3

1.51

0.0019

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