node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A2Z6QD61 | A0A2Z6QK52 | A0A2Z6QD61 | A0A2Z6QK52 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.851 |
A0A2Z6QD61 | A0A2Z6QNC7 | A0A2Z6QD61 | A0A2Z6QNC7 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | ThiF domain-containing protein. | 0.655 |
A0A2Z6QD61 | A0A2Z6QW64 | A0A2Z6QD61 | A0A2Z6QW64 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. | 0.847 |
A0A2Z6QD61 | A0A2Z6R2R8 | A0A2Z6QD61 | A0A2Z6R2R8 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.911 |
A0A2Z6QD61 | A0A2Z6REM6 | A0A2Z6QD61 | A0A2Z6REM6 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Ubiquitin-activating enzyme E1-like; Belongs to the ubiquitin-activating E1 family. | 0.711 |
A0A2Z6QD61 | A0A2Z6RUM6 | A0A2Z6QD61 | A0A2Z6RUM6 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.817 |
A0A2Z6QD61 | A0A2Z6RUV9 | A0A2Z6QD61 | A0A2Z6RUV9 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.774 |
A0A2Z6QD61 | A0A2Z6RXQ1 | A0A2Z6QD61 | A0A2Z6RXQ1 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] | 0.785 |
A0A2Z6QD61 | A0A2Z6SGX3 | A0A2Z6QD61 | A0A2Z6SGX3 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | E2_bind domain-containing protein. | 0.835 |
A0A2Z6QD61 | UBA4 | A0A2Z6QD61 | A0A2Z6R084 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Adenylyltransferase and sulfurtransferase UBA4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...] | 0.655 |
A0A2Z6QK52 | A0A2Z6QD61 | A0A2Z6QK52 | A0A2Z6QD61 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.851 |
A0A2Z6QK52 | A0A2Z6QNC7 | A0A2Z6QK52 | A0A2Z6QNC7 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | ThiF domain-containing protein. | 0.513 |
A0A2Z6QK52 | A0A2Z6QW64 | A0A2Z6QK52 | A0A2Z6QW64 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. | 0.811 |
A0A2Z6QK52 | A0A2Z6R2R8 | A0A2Z6QK52 | A0A2Z6R2R8 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.798 |
A0A2Z6QK52 | A0A2Z6REM6 | A0A2Z6QK52 | A0A2Z6REM6 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Ubiquitin-activating enzyme E1-like; Belongs to the ubiquitin-activating E1 family. | 0.544 |
A0A2Z6QK52 | A0A2Z6RUM6 | A0A2Z6QK52 | A0A2Z6RUM6 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. | 0.821 |
A0A2Z6QK52 | A0A2Z6RUV9 | A0A2Z6QK52 | A0A2Z6RUV9 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | UBIQUITIN_CONJUGAT_2 domain-containing protein. | 0.829 |
A0A2Z6QK52 | A0A2Z6RXQ1 | A0A2Z6QK52 | A0A2Z6RXQ1 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] | 0.779 |
A0A2Z6QK52 | A0A2Z6SGX3 | A0A2Z6QK52 | A0A2Z6SGX3 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | E2_bind domain-containing protein. | 0.806 |
A0A2Z6QK52 | UBA4 | A0A2Z6QK52 | A0A2Z6R084 | UBIQUITIN_CONJUGAT_2 domain-containing protein. | Adenylyltransferase and sulfurtransferase UBA4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subseque [...] | 0.515 |