A0A2Z6RYL2 protein (Rhizophagus clarus) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Coexpression

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[Homology]

Score

A0A2Z6RYL2

Uncharacterized protein. (946 aa)

Predicted Functional Partners:

A0A2Z6QCX3

0.949

A0A2Z6RWE0

0.795

A0A2Z6QM57

0.767

A0A2Z6R0A3

0.743

A0A2Z6QB25

0.732

A0A2Z6S996

0.732

A0A2Z6QMS5

0.713

A0A2Z6RJH9

0.631

A0A2Z6Q8Y5

0.628

A0A2Z6RIY6

0.628

Your Current Organism:

Rhizophagus clarus

NCBI taxonomy Id: 94130
Other names: Glomus clarum, R. clarus, Rhizoglomus clarum, Rhizophagus clarus (T.H. Nicolson & N.C. Schenck) C. Walker & A. Schuessler 2010

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2Z6Q8Y5	A0A2Z6QCX3	Uncharacterized protein.	PABS domain-containing protein; Belongs to the spermidine/spermine synthase family.	0.416
A0A2Z6Q8Y5	A0A2Z6RWE0	Uncharacterized protein.	Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Belongs to the AlaDH/PNT family.	0.628
A0A2Z6Q8Y5	A0A2Z6RYL2	Uncharacterized protein.	Uncharacterized protein.	0.628
A0A2Z6QB25	A0A2Z6QCX3	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	PABS domain-containing protein; Belongs to the spermidine/spermine synthase family.	0.890
A0A2Z6QB25	A0A2Z6QMS5	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Semialdhyde_dh domain-containing protein.	0.888
A0A2Z6QB25	A0A2Z6RJH9	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Arginase; Belongs to the arginase family.	0.887
A0A2Z6QB25	A0A2Z6RWE0	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Belongs to the AlaDH/PNT family.	0.732
A0A2Z6QB25	A0A2Z6RYL2	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	Uncharacterized protein.	0.732
A0A2Z6QCX3	A0A2Z6Q8Y5	PABS domain-containing protein; Belongs to the spermidine/spermine synthase family.	Uncharacterized protein.	0.416
A0A2Z6QCX3	A0A2Z6QB25	PABS domain-containing protein; Belongs to the spermidine/spermine synthase family.	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.890
A0A2Z6QCX3	A0A2Z6QM57	PABS domain-containing protein; Belongs to the spermidine/spermine synthase family.	Carrier domain-containing protein.	0.521
A0A2Z6QCX3	A0A2Z6RIY6	PABS domain-containing protein; Belongs to the spermidine/spermine synthase family.	NAD_binding_4 domain-containing protein.	0.416
A0A2Z6QCX3	A0A2Z6RJH9	PABS domain-containing protein; Belongs to the spermidine/spermine synthase family.	Arginase; Belongs to the arginase family.	0.944
A0A2Z6QCX3	A0A2Z6RWE0	PABS domain-containing protein; Belongs to the spermidine/spermine synthase family.	Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Belongs to the AlaDH/PNT family.	0.616
A0A2Z6QCX3	A0A2Z6RYL2	PABS domain-containing protein; Belongs to the spermidine/spermine synthase family.	Uncharacterized protein.	0.949
A0A2Z6QCX3	A0A2Z6S996	PABS domain-containing protein; Belongs to the spermidine/spermine synthase family.	Uncharacterized protein; Belongs to the Orn/Lys/Arg decarboxylase class-II family.	0.890
A0A2Z6QM57	A0A2Z6QCX3	Carrier domain-containing protein.	PABS domain-containing protein; Belongs to the spermidine/spermine synthase family.	0.521
A0A2Z6QM57	A0A2Z6R0A3	Carrier domain-containing protein.	Iso_dh domain-containing protein.	0.412
A0A2Z6QM57	A0A2Z6RWE0	Carrier domain-containing protein.	Saccharopine dehydrogenase [NAD(+), L-lysine-forming]; Belongs to the AlaDH/PNT family.	0.832
A0A2Z6QM57	A0A2Z6RYL2	Carrier domain-containing protein.	Uncharacterized protein.	0.767

page 1 of 4

Network Stats

number of nodes:

7

number of edges:

20

average node degree:

5.71

avg. local clustering coefficient:

0.952

expected number of edges:

7

PPI enrichment p-value:

2.45e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006537

Glutamate biosynthetic process

3 of 3

2.35

1.56

0.0012

GO:0044205

De novo UMP biosynthetic process

3 of 9

1.87

1.4

0.0015

GO:0009084

Glutamine family amino acid biosynthetic process

4 of 17

1.72

1.38

0.0012

GO:0006221

Pyrimidine nucleotide biosynthetic process

4 of 17

1.72

1.38

0.0012

GO:0006207

De novo pyrimidine nucleobase biosynthetic process

2 of 4

2.05

1.03

0.0113

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016491

Oxidoreductase activity

8 of 129

1.14

1.31

5.49e-06

GO:0051536

Iron-sulfur cluster binding

5 of 58

1.29

1.11

0.00099

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:666

Ribonucleoside monophosphate biosynthetic process, and Nitrogen metabolism

7 of 36

1.64

2.63

5.16e-08

CL:696

De novo UMP biosynthetic process

3 of 10

1.83

1.39

0.0015

CL:661

Carboxylic acid metabolic process, and Ribonucleoside monophosphate metabolic process

9 of 199

1.01

1.13

1.60e-06

CL:699

De novo UMP biosynthetic process

2 of 5

1.95

0.86

0.0237

CL:718

Nitrogen metabolism

2 of 7

1.81

0.75

0.0364

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00250

Alanine, aspartate and glutamate metabolism

4 of 25

1.55

1.42

0.00047

map00910

Nitrogen metabolism

3 of 13

1.71

1.3

0.0018

map00650

Butanoate metabolism

2 of 10

1.65

0.82

0.0229

map00240

Pyrimidine metabolism

3 of 38

1.25

0.75

0.0157

map01120

Microbial metabolism in diverse environments

5 of 141

0.9

0.63

0.0076

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990204

Oxidoreductase complex

3 of 13

1.71

1.06

0.0069

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0665

Pyrimidine biosynthesis

3 of 11

1.79

1.32

0.0020

KW-0560

Oxidoreductase

5 of 62

1.26

1.09

0.00090

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF07992

Pyridine nucleotide-disulphide oxidoreductase

3 of 6

2.05

1.4

0.0020

PF14691

Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster

2 of 2

2.35

0.93

0.0197

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023753

FAD/NAD(P)-binding domain

3 of 6

2.05

1.18

0.0055

IPR036188

FAD/NAD(P)-binding domain superfamily

3 of 12

1.75

0.92

0.0148

IPR036873

Rhodanese-like domain superfamily

2 of 2

2.35

0.78

0.0367

IPR028261

Dihydroprymidine dehydrogenase domain II

2 of 2

2.35

0.78

0.0367

IPR009051

Alpha-helical ferredoxin

2 of 2

2.35

0.78

0.0367

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00450

Rhodanese Homology Domain

2 of 2

2.35

1.09

0.0098

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