A0A2Z6S5C7 protein (Rhizophagus clarus) - STRING interaction network

Nodes:

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second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A2Z6S5C7

Uncharacterized protein. (1294 aa)

Predicted Functional Partners:

A0A2Z6S7B9

0.541

A0A2Z6RCS4

0.518

A0A2Z6R8A3

0.511

A0A2Z6RXF9

0.430

A0A2Z6RRC7

0.422

Your Current Organism:

Rhizophagus clarus

NCBI taxonomy Id: 94130
Other names: Glomus clarum, R. clarus, Rhizoglomus clarum, Rhizophagus clarus (T.H. Nicolson & N.C. Schenck) C. Walker & A. Schuessler 2010

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A2Z6R8A3	A0A2Z6RCS4	Uncharacterized protein.	Uncharacterized protein.	0.496
A0A2Z6R8A3	A0A2Z6RRC7	Uncharacterized protein.	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	0.789
A0A2Z6R8A3	A0A2Z6RXF9	Uncharacterized protein.	Glycerol-3-phosphate dehydrogenase [NAD(+)].	0.708
A0A2Z6R8A3	A0A2Z6S5C7	Uncharacterized protein.	Uncharacterized protein.	0.511
A0A2Z6R8A3	A0A2Z6S7B9	Uncharacterized protein.	Uncharacterized protein.	0.942
A0A2Z6RCS4	A0A2Z6R8A3	Uncharacterized protein.	Uncharacterized protein.	0.496
A0A2Z6RCS4	A0A2Z6S5C7	Uncharacterized protein.	Uncharacterized protein.	0.518
A0A2Z6RCS4	A0A2Z6S7B9	Uncharacterized protein.	Uncharacterized protein.	0.496
A0A2Z6RRC7	A0A2Z6R8A3	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Uncharacterized protein.	0.789
A0A2Z6RRC7	A0A2Z6RXF9	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Glycerol-3-phosphate dehydrogenase [NAD(+)].	0.852
A0A2Z6RRC7	A0A2Z6S5C7	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Uncharacterized protein.	0.422
A0A2Z6RRC7	A0A2Z6S7B9	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	Uncharacterized protein.	0.818
A0A2Z6RXF9	A0A2Z6R8A3	Glycerol-3-phosphate dehydrogenase [NAD(+)].	Uncharacterized protein.	0.708
A0A2Z6RXF9	A0A2Z6RRC7	Glycerol-3-phosphate dehydrogenase [NAD(+)].	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	0.852
A0A2Z6RXF9	A0A2Z6S5C7	Glycerol-3-phosphate dehydrogenase [NAD(+)].	Uncharacterized protein.	0.430
A0A2Z6RXF9	A0A2Z6S7B9	Glycerol-3-phosphate dehydrogenase [NAD(+)].	Uncharacterized protein.	0.710
A0A2Z6S5C7	A0A2Z6R8A3	Uncharacterized protein.	Uncharacterized protein.	0.511
A0A2Z6S5C7	A0A2Z6RCS4	Uncharacterized protein.	Uncharacterized protein.	0.518
A0A2Z6S5C7	A0A2Z6RRC7	Uncharacterized protein.	1-acyl-sn-glycerol-3-phosphate acyltransferase; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.	0.422
A0A2Z6S5C7	A0A2Z6RXF9	Uncharacterized protein.	Glycerol-3-phosphate dehydrogenase [NAD(+)].	0.430

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

14

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042176

Regulation of protein catabolic process

5 of 28

2.18

3.49

5.69e-08

GO:0010498

Proteasomal protein catabolic process

8 of 142

1.67

3.21

2.81e-10

GO:0051603

Proteolysis involved in protein catabolic process

10 of 235

1.55

3.09

5.48e-12

GO:0006511

Ubiquitin-dependent protein catabolic process

9 of 208

1.56

2.94

8.65e-11

GO:0043248

Proteasome assembly

4 of 19

2.25

2.88

1.98e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0036402

Proteasome-activating activity

3 of 6

2.62

2.04

0.00017

GO:0004298

Threonine-type endopeptidase activity

2 of 5

2.53

0.92

0.0213

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000502

Proteasome complex

11 of 35

2.42

9.97

1.08e-23

GO:0005838

Proteasome regulatory particle

9 of 20

2.58

9.13

8.60e-20

GO:0008541

Proteasome regulatory particle, lid subcomplex

5 of 10

2.62

4.98

2.59e-10

GO:0008540

Proteasome regulatory particle, base subcomplex

4 of 9

2.57

3.75

7.23e-08

GO:0019774

Proteasome core complex, beta-subunit complex

2 of 7

2.38

1.33

0.0035

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1460

Proteasome complex

11 of 33

2.45

10.08

1.23e-23

CL:1461

Proteasome complex

8 of 28

2.38

6.99

7.87e-16

CL:1463

Proteasome accessory complex

6 of 14

2.56

5.77

3.82e-12

CL:1516

Proteasome regulatory particle, lid subcomplex

3 of 5

2.7

2.67

1.17e-05

CL:1466

Proteasome accessory complex

3 of 9

2.45

2.33

4.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03050

Proteasome

11 of 40

2.36

9.72

6.99e-24

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1236978

Cross-presentation of soluble exogenous antigens (endosomes)

11 of 38

2.39

9.66

2.66e-23

MAP-1236975

Antigen processing-Cross presentation

11 of 39

2.37

9.6

2.66e-23

MAP-5689880

Ub-specific processing proteases

11 of 72

2.11

7.46

4.92e-21

MAP-5688426

Deubiquitination

11 of 101

1.96

6.29

1.20e-19

MAP-983169

Class I MHC mediated antigen processing & presentation

11 of 164

1.75

4.74

1.57e-17

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000502

Proteasome complex

11 of 81

2.06

6.92

5.10e-20

GOCC:0005838

Proteasome regulatory particle

4 of 16

2.32

3.06

1.03e-06

GOCC:0008540

Proteasome regulatory particle, base subcomplex

3 of 8

2.5

2.45

2.54e-05

GOCC:0019774

Proteasome core complex, beta-subunit complex

2 of 7

2.38

1.24

0.0051

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0647

Proteasome

5 of 22

2.28

3.83

1.62e-08

KW-0645

Protease

3 of 107

1.37

0.69

0.0312

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000717

Proteasome component (PCI) domain

5 of 17

2.39

3.68

5.95e-08

IPR036390

Winged helix DNA-binding domain superfamily

5 of 60

1.84

2.27

9.12e-06

IPR005937

26S proteasome regulatory subunit P45-like

3 of 6

2.62

2.17

9.68e-05

IPR003960

ATPase, AAA-type, conserved site

3 of 21

2.08

1.44

0.0017

IPR003959

ATPase, AAA-type, core

3 of 38

1.82

1.08

0.0072

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00088

Motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

5 of 13

2.51

4.43

2.27e-09

SM00753

PCI/PINT associated module

2 of 4

2.62

1.37

0.0031

SM00382

ATPases associated with a variety of cellular activities

3 of 99

1.4

0.76

0.0218

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