close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSMMOP00000001426Growth arrest and DNA-damage-inducible, gamma a. (159 aa)    
Predicted Functional Partners:
ENSMMOP00000010116
Mitogen-activated protein kinase kinase kinase 4.
    
 0.950
ENSMMOP00000017045
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
    
 0.936
ENSMMOP00000006885
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
    
 0.929
ENSMMOP00000016395
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
     
 0.904
CCNB2
Cyclin B2; Belongs to the cyclin family.
    
 0.889
ENSMMOP00000022835
Cyclin B2; Belongs to the cyclin family.
    
 0.889
ENSMMOP00000015670
Cyclin B1; Belongs to the cyclin family.
    
 0.868
ENSMMOP00000006898
Cyclin N-terminal domain containing 2; Belongs to the cyclin family.
    
 0.867
ENSMMOP00000009926
Ribosomal_L7Ae domain-containing protein.
  
 
0.862
ENSMMOP00000019188
Cyclin B3; Belongs to the cyclin family.
    
 0.851
Your Current Organism:
Mola mola
NCBI taxonomy Id: 94237
Other names: M. mola, ocean sunfish
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.