Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ENSMMOP00000001426Growth arrest and DNA-damage-inducible, gamma a. (159 aa)    
Predicted Functional Partners:
ENSMMOP00000010116
Mitogen-activated protein kinase kinase kinase 4.
    
 0.992
ENSMMOP00000017045
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.
    
 0.976
ENSMMOP00000000093
RWD domain containing 2B.
    
   0.960
ENSMMOP00000006885
Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.
    
 0.917
ENSMMOP00000016395
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
     
 0.914
ENSMMOP00000019188
Cyclin B3; Belongs to the cyclin family.
    
 0.905
ENSMMOP00000009926
Ribosomal_L7Ae domain-containing protein.
   
 
  0.889
ENSMMOP00000000386
Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.
    
 0.886
ENSMMOP00000026552
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
    
 0.886
ENSMMOP00000029018
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
    
 0.886
Your Current Organism:
Mola mola
NCBI taxonomy Id: 94237
Other names: M. mola, ocean sunfish
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