STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CLSPNClaspin. (1103 aa)    
Predicted Functional Partners:
ENSMMOP00000024679
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
   
 0.991
ENSMMOP00000015537
Replication protein A3.
    
 0.990
ENSMMOP00000015318
CDC45 cell division cycle 45 homolog (S. cerevisiae).
   
 0.988
ENSMMOP00000012316
DNA helicase; Belongs to the MCM family.
   
 0.981
ENSMMOP00000008863
Primase and polymerase (DNA-directed).
   
 
 0.974
RPA1
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 0.974
ENSMMOP00000018889
Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.
   
 0.974
ENSMMOP00000000111
Timeless circadian clock.
   
 
 0.970
ENSMMOP00000010246
DNA helicase; Belongs to the MCM family.
   
 0.958
ENSMMOP00000025989
GINS complex subunit 3.
   
 
 0.956
Your Current Organism:
Mola mola
NCBI taxonomy Id: 94237
Other names: M. mola, ocean sunfish
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.