EGS37461.1 protein (Lactobacillus oris) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

EGS37461.1

Hypothetical protein. (142 aa)

Predicted Functional Partners:

EGS37481.1

0.800

EGS37390.1

0.769

EGS37353.1

0.753

EGS37360.1

0.738

EGS37315.1

0.733

EGS37339.1

0.621

EGS37969.1

0.585

EGS37957.1

0.577

EGS38503.1

0.549

EGS37402.1

0.500

Your Current Organism:

Lactobacillus oris

NCBI taxonomy Id: 944562
Other names: L. oris F0423, Lactobacillus oris F0423, Lactobacillus oris str. F0423, Lactobacillus oris strain F0423

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGS37315.1	EGS37339.1	HMPREF9102_1488	HMPREF9102_1482	Hypothetical protein.	Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.	0.940
EGS37315.1	EGS37353.1	HMPREF9102_1488	HMPREF9102_1486	Hypothetical protein.	Hypothetical protein.	0.944
EGS37315.1	EGS37360.1	HMPREF9102_1488	HMPREF9102_1493	Hypothetical protein.	Hypothetical protein.	0.815
EGS37315.1	EGS37402.1	HMPREF9102_1488	HMPREF9102_1494	Hypothetical protein.	Transporter, major facilitator family protein; Identified by match to protein family HMM PF07690.	0.758
EGS37315.1	EGS37461.1	HMPREF9102_1488	HMPREF9102_1502	Hypothetical protein.	Hypothetical protein.	0.733
EGS37315.1	EGS37481.1	HMPREF9102_1488	HMPREF9102_1500	Hypothetical protein.	ABC transporter, substrate-binding protein; Identified by match to protein family HMM PF01497.	0.766
EGS37339.1	EGS37315.1	HMPREF9102_1482	HMPREF9102_1488	Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.	Hypothetical protein.	0.940
EGS37339.1	EGS37353.1	HMPREF9102_1482	HMPREF9102_1486	Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.	Hypothetical protein.	0.968
EGS37339.1	EGS37360.1	HMPREF9102_1482	HMPREF9102_1493	Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.	Hypothetical protein.	0.699
EGS37339.1	EGS37402.1	HMPREF9102_1482	HMPREF9102_1494	Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.	Transporter, major facilitator family protein; Identified by match to protein family HMM PF07690.	0.721
EGS37339.1	EGS37461.1	HMPREF9102_1482	HMPREF9102_1502	Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.	Hypothetical protein.	0.621
EGS37339.1	EGS37481.1	HMPREF9102_1482	HMPREF9102_1500	Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.	ABC transporter, substrate-binding protein; Identified by match to protein family HMM PF01497.	0.669
EGS37353.1	EGS37315.1	HMPREF9102_1486	HMPREF9102_1488	Hypothetical protein.	Hypothetical protein.	0.944
EGS37353.1	EGS37339.1	HMPREF9102_1486	HMPREF9102_1482	Hypothetical protein.	Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.	0.968
EGS37353.1	EGS37360.1	HMPREF9102_1486	HMPREF9102_1493	Hypothetical protein.	Hypothetical protein.	0.823
EGS37353.1	EGS37402.1	HMPREF9102_1486	HMPREF9102_1494	Hypothetical protein.	Transporter, major facilitator family protein; Identified by match to protein family HMM PF07690.	0.728
EGS37353.1	EGS37461.1	HMPREF9102_1486	HMPREF9102_1502	Hypothetical protein.	Hypothetical protein.	0.753
EGS37353.1	EGS37481.1	HMPREF9102_1486	HMPREF9102_1500	Hypothetical protein.	ABC transporter, substrate-binding protein; Identified by match to protein family HMM PF01497.	0.788
EGS37360.1	EGS37315.1	HMPREF9102_1493	HMPREF9102_1488	Hypothetical protein.	Hypothetical protein.	0.815
EGS37360.1	EGS37339.1	HMPREF9102_1493	HMPREF9102_1482	Hypothetical protein.	Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.	0.699

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.909

expected number of edges:

12

PPI enrichment p-value:

0.000132

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 106

1.19

1.66

8.07e-09

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 247

0.86

0.95

6.02e-08

GO:1901566

Organonitrogen compound biosynthetic process

11 of 261

0.84

0.9

8.96e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

9 of 54

1.43

2.4

1.09e-09

GO:0019843

rRNA binding

7 of 41

1.44

2.06

2.97e-07

GO:0003676

Nucleic acid binding

8 of 320

0.61

0.43

0.0106

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044391

Ribosomal subunit

6 of 15

1.81

3.22

7.51e-09

GO:0015935

Small ribosomal subunit

4 of 6

2.04

2.74

1.71e-06

GO:0005840

Ribosome

9 of 56

1.42

2.43

2.68e-10

GO:0015934

Large ribosomal subunit

2 of 9

1.56

0.88

0.0146

GO:0005622

Intracellular anatomical structure

10 of 705

0.36

0.3

0.0057

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:112

Ribosome

8 of 45

1.46

2.4

4.03e-09

CL:105

Ribosome, and Translation regulator activity

9 of 64

1.36

2.14

3.45e-09

CL:113

rRNA-binding, and Elongation factor

5 of 32

1.41

1.6

2.75e-05

CL:115

rRNA-binding

4 of 26

1.4

1.31

0.00042

CL:176

Ribosome

3 of 13

1.58

1.23

0.0019

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

gha03010

Ribosome

9 of 53

1.44

2.54

1.47e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044391

Ribosomal subunit

7 of 23

1.7

2.95

7.38e-09

GOCC:0022626

Cytosolic ribosome

6 of 19

1.71

2.72

8.47e-08

GOCC:0005840

Ribosome

8 of 43

1.48

2.42

7.38e-09

GOCC:0022627

Cytosolic small ribosomal subunit

4 of 13

1.7

1.91

3.93e-05

GOCC:0015934

Large ribosomal subunit

3 of 10

1.69

1.42

0.00088

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

9 of 56

1.42

2.4

4.93e-10

KW-0699

rRNA-binding

7 of 38

1.48

2.25

6.18e-08

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