dexB-2 protein (Tetragenococcus halophilus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

dexB-2

Glucan 1,6-alpha-glucosidase; Protein synonym:dextran glucosidase. (544 aa)

Predicted Functional Partners:

TEH_12160

0.681

TEH_03460

0.594

TEH_21460

0.594

bglP

0.580

bglP-2

0.580

bglP-3

0.580

bglP-4

0.580

TEH_12180

0.568

TEH_12150

0.550

TEH_12190

0.502

Your Current Organism:

Tetragenococcus halophilus

NCBI taxonomy Id: 945021
Other names: T. halophilus NBRC 12172, Tetragenococcus halophilus NBRC 12172, Tetragenococcus halophilus str. NBRC 12172, Tetragenococcus halophilus strain NBRC 12172

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
TEH_03460	TEH_12160	TEH_03460	TEH_12160	Putative serine/threonine exchanger transporter.	Glucosidase.	0.594
TEH_03460	dexB-2	TEH_03460	TEH_12170	Putative serine/threonine exchanger transporter.	Glucan 1,6-alpha-glucosidase; Protein synonym:dextran glucosidase.	0.594
TEH_12150	TEH_12160	TEH_12150	TEH_12160	Putative LacI family transcriptional regulator.	Glucosidase.	0.626
TEH_12150	dexB-2	TEH_12150	TEH_12170	Putative LacI family transcriptional regulator.	Glucan 1,6-alpha-glucosidase; Protein synonym:dextran glucosidase.	0.550
TEH_12160	TEH_03460	TEH_12160	TEH_03460	Glucosidase.	Putative serine/threonine exchanger transporter.	0.594
TEH_12160	TEH_12150	TEH_12160	TEH_12150	Glucosidase.	Putative LacI family transcriptional regulator.	0.626
TEH_12160	TEH_12180	TEH_12160	TEH_12180	Glucosidase.	Putative alpha-glucoside-specific phosphotransferase system enzyme IIB component; Protein synonym:PTS alpha-glucoside-specific EIIB component.	0.520
TEH_12160	TEH_12190	TEH_12160	TEH_12190	Glucosidase.	Putative alpha-glucoside-specific phosphotransferase system enzyme IIC component; Protein synonym:PTS alpha-glucoside-specific EIIC component.	0.468
TEH_12160	TEH_21460	TEH_12160	TEH_21460	Glucosidase.	Putative amino acid permease.	0.594
TEH_12160	bglP	TEH_12160	TEH_04790	Glucosidase.	Beta-glucoside-specific phosphotransferase system enzyme II; Protein synonym:PTS beta-glucoside-specific EIIBCA component; protein synonym:protein-Npi-phosphohistidine--sugar phosphotransferase.	0.580
TEH_12160	bglP-2	TEH_12160	TEH_05130	Glucosidase.	Beta-glucoside-specific phosphotransferase system enzyme II; Protein synonym:PTS beta-glucoside-specific EIIBCA component; protein synonym:protein-Npi-phosphohistidine--sugar phosphotransferase.	0.580
TEH_12160	bglP-3	TEH_12160	TEH_20340	Glucosidase.	Beta-glucoside-specific phosphotransferase system enzyme II; Protein synonym:PTS beta-glucoside-specific EIIBCA component; protein synonym:protein-Npi-phosphohistidine--sugar phosphotransferase.	0.580
TEH_12160	bglP-4	TEH_12160	TEH_24050	Glucosidase.	Beta-glucoside-specific phosphotransferase system enzyme II; Protein synonym:PTS beta-glucoside-specific EIIBCA component; protein synonym:protein-Npi-phosphohistidine--sugar phosphotransferase.	0.580
TEH_12160	dexB-2	TEH_12160	TEH_12170	Glucosidase.	Glucan 1,6-alpha-glucosidase; Protein synonym:dextran glucosidase.	0.681
TEH_12180	TEH_12160	TEH_12180	TEH_12160	Putative alpha-glucoside-specific phosphotransferase system enzyme IIB component; Protein synonym:PTS alpha-glucoside-specific EIIB component.	Glucosidase.	0.520
TEH_12180	TEH_12190	TEH_12180	TEH_12190	Putative alpha-glucoside-specific phosphotransferase system enzyme IIB component; Protein synonym:PTS alpha-glucoside-specific EIIB component.	Putative alpha-glucoside-specific phosphotransferase system enzyme IIC component; Protein synonym:PTS alpha-glucoside-specific EIIC component.	0.990
TEH_12180	bglP	TEH_12180	TEH_04790	Putative alpha-glucoside-specific phosphotransferase system enzyme IIB component; Protein synonym:PTS alpha-glucoside-specific EIIB component.	Beta-glucoside-specific phosphotransferase system enzyme II; Protein synonym:PTS beta-glucoside-specific EIIBCA component; protein synonym:protein-Npi-phosphohistidine--sugar phosphotransferase.	0.575
TEH_12180	bglP-2	TEH_12180	TEH_05130	Putative alpha-glucoside-specific phosphotransferase system enzyme IIB component; Protein synonym:PTS alpha-glucoside-specific EIIB component.	Beta-glucoside-specific phosphotransferase system enzyme II; Protein synonym:PTS beta-glucoside-specific EIIBCA component; protein synonym:protein-Npi-phosphohistidine--sugar phosphotransferase.	0.572
TEH_12180	bglP-3	TEH_12180	TEH_20340	Putative alpha-glucoside-specific phosphotransferase system enzyme IIB component; Protein synonym:PTS alpha-glucoside-specific EIIB component.	Beta-glucoside-specific phosphotransferase system enzyme II; Protein synonym:PTS beta-glucoside-specific EIIBCA component; protein synonym:protein-Npi-phosphohistidine--sugar phosphotransferase.	0.531
TEH_12180	bglP-4	TEH_12180	TEH_24050	Putative alpha-glucoside-specific phosphotransferase system enzyme IIB component; Protein synonym:PTS alpha-glucoside-specific EIIB component.	Beta-glucoside-specific phosphotransferase system enzyme II; Protein synonym:PTS beta-glucoside-specific EIIBCA component; protein synonym:protein-Npi-phosphohistidine--sugar phosphotransferase.	0.570

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.917

expected number of edges:

14

PPI enrichment p-value:

2.83e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

4 of 24

1.61

1.17

0.0030

GO:0019605

Butyrate metabolic process

2 of 2

2.39

0.84

0.0286

GO:0017000

Antibiotic biosynthetic process

3 of 17

1.64

0.77

0.0286

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

3 of 3

2.39

1.74

0.00056

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1312

Mixed, incl. AMP-binding enzyme, and Butyrate metabolic process

7 of 10

2.24

5.06

1.07e-11

CL:1286

Mixed, incl. Fatty acid metabolism, and KR domain

8 of 23

1.93

4.31

1.07e-11

CL:1314

AMP-binding enzyme, and Polyketide synthase, ketoreductase domain

3 of 5

2.17

1.84

0.00028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

4 of 6

2.21

2.6

7.15e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

2 of 4

2.09

0.74

0.0420

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

5 of 8

2.19

3.27

2.05e-07

PF16197

Ketoacyl-synthetase C-terminal extension

3 of 3

2.39

1.96

0.00021

PF02801

Beta-ketoacyl synthase, C-terminal domain

3 of 4

2.27

1.9

0.00024

PF00109

Beta-ketoacyl synthase, N-terminal domain

3 of 4

2.27

1.9

0.00024

PF00501

AMP-binding enzyme

2 of 4

2.09

0.92

0.0190

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

5 of 8

2.19

3.09

5.38e-07

IPR009081

Phosphopantetheine binding ACP domain

5 of 8

2.19

3.09

5.38e-07

IPR032821

Polyketide synthase, C-terminal extension

3 of 3

2.39

1.83

0.00037

IPR020841

Polyketide synthase, beta-ketoacyl synthase domain

3 of 4

2.27

1.75

0.00048

IPR018201

Beta-ketoacyl synthase, active site

3 of 4

2.27

1.75

0.00048

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 2

2.39

1.09

0.0097

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (18%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About