BESB_023210 protein (Besnoitia besnoiti) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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BESB_023210

Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (557 aa)

Predicted Functional Partners:

BESB_086410

0.971

BESB_001860

0.971

BESB_074920

0.899

BESB_067460

0.890

BESB_061330

0.890

BESB_044890

0.885

BESB_067990

0.884

BESB_062800

0.880

BESB_011170

0.879

BESB_000430

0.879

Your Current Organism:

Besnoitia besnoiti

NCBI taxonomy Id: 94643
Other names: B. besnoiti

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BESB_000430	BESB_001860	A0A2A9MMM9	A0A2A9MKT2	Ribosomal protein RPS14; Belongs to the universal ribosomal protein uS11 family.	Elongation factor Tu.	0.981
BESB_000430	BESB_011170	A0A2A9MMM9	A0A2A9ML78	Ribosomal protein RPS14; Belongs to the universal ribosomal protein uS11 family.	Putative ribosomal protein L20; Belongs to the bacterial ribosomal protein bL20 family.	0.999
BESB_000430	BESB_023210	A0A2A9MMM9	A0A2A9M1H7	Ribosomal protein RPS14; Belongs to the universal ribosomal protein uS11 family.	Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.879
BESB_000430	BESB_044890	A0A2A9MMM9	A0A2A9MKY7	Ribosomal protein RPS14; Belongs to the universal ribosomal protein uS11 family.	Putative 30S ribosomal protein S16.	0.999
BESB_000430	BESB_061330	A0A2A9MMM9	A0A2A9MH10	Ribosomal protein RPS14; Belongs to the universal ribosomal protein uS11 family.	Uncharacterized protein.	0.996
BESB_000430	BESB_062800	A0A2A9MMM9	A0A2A9MID2	Ribosomal protein RPS14; Belongs to the universal ribosomal protein uS11 family.	Ribosomal protein RPS20.	0.999
BESB_000430	BESB_067460	A0A2A9MMM9	A0A2A9MGD3	Ribosomal protein RPS14; Belongs to the universal ribosomal protein uS11 family.	S1 RNA binding domain-containing protein.	0.991
BESB_000430	BESB_067990	A0A2A9MMM9	A0A2A9MFL7	Ribosomal protein RPS14; Belongs to the universal ribosomal protein uS11 family.	Putative trigger factor protein.	0.992
BESB_000430	BESB_074920	A0A2A9MMM9	A0A2A9MG26	Ribosomal protein RPS14; Belongs to the universal ribosomal protein uS11 family.	Ribosomal protein L19 protein.	0.999
BESB_000430	BESB_086410	A0A2A9MMM9	A0A2A9LXQ5	Ribosomal protein RPS14; Belongs to the universal ribosomal protein uS11 family.	Putative elongation factor tu, apicoplast.	0.981
BESB_001860	BESB_000430	A0A2A9MKT2	A0A2A9MMM9	Elongation factor Tu.	Ribosomal protein RPS14; Belongs to the universal ribosomal protein uS11 family.	0.981
BESB_001860	BESB_011170	A0A2A9MKT2	A0A2A9ML78	Elongation factor Tu.	Putative ribosomal protein L20; Belongs to the bacterial ribosomal protein bL20 family.	0.977
BESB_001860	BESB_023210	A0A2A9MKT2	A0A2A9M1H7	Elongation factor Tu.	Elongation factor Ts, mitochondrial; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family.	0.971
BESB_001860	BESB_044890	A0A2A9MKT2	A0A2A9MKY7	Elongation factor Tu.	Putative 30S ribosomal protein S16.	0.978
BESB_001860	BESB_061330	A0A2A9MKT2	A0A2A9MH10	Elongation factor Tu.	Uncharacterized protein.	0.881
BESB_001860	BESB_062800	A0A2A9MKT2	A0A2A9MID2	Elongation factor Tu.	Ribosomal protein RPS20.	0.981
BESB_001860	BESB_067460	A0A2A9MKT2	A0A2A9MGD3	Elongation factor Tu.	S1 RNA binding domain-containing protein.	0.881
BESB_001860	BESB_067990	A0A2A9MKT2	A0A2A9MFL7	Elongation factor Tu.	Putative trigger factor protein.	0.737
BESB_001860	BESB_074920	A0A2A9MKT2	A0A2A9MG26	Elongation factor Tu.	Ribosomal protein L19 protein.	0.976
BESB_011170	BESB_000430	A0A2A9ML78	A0A2A9MMM9	Putative ribosomal protein L20; Belongs to the bacterial ribosomal protein bL20 family.	Ribosomal protein RPS14; Belongs to the universal ribosomal protein uS11 family.	0.999

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Network Stats

number of nodes:

10

number of edges:

23

average node degree:

4.6

avg. local clustering coefficient:

0.815

expected number of edges:

9

PPI enrichment p-value:

8.66e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6148

IBR domain, and Fucose metabolism

2 of 6

2.89

1.56

0.0015

CL:5896

14-3-3 domain, and RAF activation

2 of 5

2.97

1.56

0.0015

CL:3521

LAG1, DNA binding, and Protein of unknown function DUF6699

2 of 5

2.97

1.56

0.0015

CL:5882

Mixed, incl. Protein kinase domain, and Non-membrane spanning protein tyrosine kinase activity

4 of 162

1.76

1.36

0.0015

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03050

Proteasome

2 of 49

1.98

0.79

0.0330

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-109606

Intrinsic Pathway for Apoptosis

2 of 7

2.82

1.24

0.0057

MAP-75035

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

2 of 13

2.55

1.23

0.0057

MAP-5625740

RHO GTPases activate PKNs

2 of 10

2.67

1.23

0.0057

MAP-109581

Apoptosis

2 of 23

2.3

1.04

0.0118

MAP-5357801

Programmed Cell Death

2 of 35

2.12

0.9

0.0209

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR040159

Suppressor of hairless-like

2 of 2

3.37

1.39

0.0032

IPR037095

RBP-J/Cbf11, DNA binding domain superfamily

2 of 2

3.37

1.39

0.0032

IPR036815

14-3-3 domain superfamily

2 of 2

3.37

1.39

0.0032

IPR036358

Beta-trefoil domain superfamily

2 of 2

3.37

1.39

0.0032

IPR023410

14-3-3 domain

2 of 2

3.37

1.39

0.0032

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01268

Beta-trefoil DNA-binding domain

2 of 2

3.37

1.93

0.00034

SM01267

LAG1, DNA binding

2 of 2

3.37

1.93

0.00034

SM00101

14-3-3 homologues

2 of 2

3.37

1.93

0.00034

SM00248

Ankyrin repeats

2 of 67

1.84

0.77

0.0327

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