BESB_046400 protein (Besnoitia besnoiti) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

BESB_046400

Uncharacterized protein. (549 aa)

Predicted Functional Partners:

BESB_037490

0.751

BESB_012830

0.660

BESB_001440

0.599

BESB_056910

0.593

BESB_074090

0.592

BESB_000080

0.592

BESB_034570

0.547

BESB_062450

0.509

BESB_034790

0.509

BESB_014690

0.504

Your Current Organism:

Besnoitia besnoiti

NCBI taxonomy Id: 94643
Other names: B. besnoiti

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BESB_000080	BESB_012830	A0A2A9MN98	A0A2A9M8N4	Flagellar associated protein.	Autophagy-related protein.	0.648
BESB_000080	BESB_014690	A0A2A9MN98	A0A2A9MA95	Flagellar associated protein.	Ankyrin repeat-containing protein.	0.472
BESB_000080	BESB_034570	A0A2A9MN98	A0A2A9MGF6	Flagellar associated protein.	DPCD family protein.	0.691
BESB_000080	BESB_046400	A0A2A9MN98	A0A2A9MD76	Flagellar associated protein.	Uncharacterized protein.	0.592
BESB_001440	BESB_014690	A0A2A9MPP1	A0A2A9MA95	Peptidase C50 domain-containing protein.	Ankyrin repeat-containing protein.	0.724
BESB_001440	BESB_034790	A0A2A9MPP1	A0A2A9ML40	Peptidase C50 domain-containing protein.	Serine/threonine-protein phosphatase.	0.704
BESB_001440	BESB_046400	A0A2A9MPP1	A0A2A9MD76	Peptidase C50 domain-containing protein.	Uncharacterized protein.	0.599
BESB_001440	BESB_056910	A0A2A9MPP1	A0A2A9MKT1	Peptidase C50 domain-containing protein.	HEAT repeat-containing protein.	0.769
BESB_001440	BESB_062450	A0A2A9MPP1	A0A2A9MA70	Peptidase C50 domain-containing protein.	Serine/threonine-protein phosphatase.	0.704
BESB_012830	BESB_000080	A0A2A9M8N4	A0A2A9MN98	Autophagy-related protein.	Flagellar associated protein.	0.648
BESB_012830	BESB_014690	A0A2A9M8N4	A0A2A9MA95	Autophagy-related protein.	Ankyrin repeat-containing protein.	0.437
BESB_012830	BESB_046400	A0A2A9M8N4	A0A2A9MD76	Autophagy-related protein.	Uncharacterized protein.	0.660
BESB_012830	BESB_074090	A0A2A9M8N4	A0A2A9MF40	Autophagy-related protein.	Uncharacterized protein.	0.648
BESB_014690	BESB_000080	A0A2A9MA95	A0A2A9MN98	Ankyrin repeat-containing protein.	Flagellar associated protein.	0.472
BESB_014690	BESB_001440	A0A2A9MA95	A0A2A9MPP1	Ankyrin repeat-containing protein.	Peptidase C50 domain-containing protein.	0.724
BESB_014690	BESB_012830	A0A2A9MA95	A0A2A9M8N4	Ankyrin repeat-containing protein.	Autophagy-related protein.	0.437
BESB_014690	BESB_034570	A0A2A9MA95	A0A2A9MGF6	Ankyrin repeat-containing protein.	DPCD family protein.	0.527
BESB_014690	BESB_034790	A0A2A9MA95	A0A2A9ML40	Ankyrin repeat-containing protein.	Serine/threonine-protein phosphatase.	0.830
BESB_014690	BESB_037490	A0A2A9MA95	A0A2A9MLS0	Ankyrin repeat-containing protein.	Leucine rich repeat-containing protein.	0.989
BESB_014690	BESB_046400	A0A2A9MA95	A0A2A9MD76	Ankyrin repeat-containing protein.	Uncharacterized protein.	0.504

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

14

PPI enrichment p-value:

1.33e-15

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007165

Signal transduction

10 of 151

1.27

1.95

1.33e-09

GO:0036211

Protein modification process

4 of 77

1.17

0.71

0.0172

GO:0000160

Phosphorelay signal transduction system

4 of 81

1.15

0.69

0.0187

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016772

Transferase activity, transferring phosphorus-containing groups

8 of 179

1.1

1.2

1.36e-05

GO:0000155

Phosphorelay sensor kinase activity

3 of 33

1.41

0.62

0.0499

GO:0016740

Transferase activity

9 of 486

0.72

0.59

0.00081

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

10 of 624

0.66

0.57

0.00013

GO:0016021

Integral component of membrane

9 of 771

0.52

0.39

0.0052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3233

PAS domain, and Helix-turn-helix domain

5 of 19

1.87

2.64

1.05e-06

CL:3202

Signaling, and Diguanylate cyclase activity

9 of 114

1.35

2.15

1.47e-09

CL:3259

Mixed, incl. HPT domain superfamily, and Helix-turn-helix domain

3 of 6

2.15

2.01

0.00012

CL:3201

Signaling, and Diguanylate cyclase activity

10 of 158

1.25

1.9

1.09e-09

CL:3203

Signaling, and Diguanylate cyclase activity

7 of 106

1.27

1.59

2.22e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02020

Two-component system

11 of 403

0.89

1.01

2.36e-08

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016020

Membrane

9 of 719

0.55

0.37

0.0179

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

5 of 57

1.4

1.44

0.00012

KW-0418

Kinase

6 of 86

1.3

1.4

4.96e-05

KW-0808

Transferase

7 of 354

0.75

0.56

0.0041

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000014

PAS domain

7 of 33

1.78

3.08

1.26e-08

IPR035965

PAS domain superfamily

7 of 34

1.77

3.06

1.26e-08

IPR004358

Signal transduction histidine kinase-related protein, C-terminal

6 of 24

1.85

2.98

8.40e-08

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

6 of 27

1.8

2.84

1.17e-07

IPR005467

Histidine kinase domain

6 of 29

1.77

2.77

1.37e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

7 of 29

1.84

3.6

4.76e-10

SM00387

Histidine kinase-like ATPases

7 of 39

1.71

3.14

1.51e-09

SM00091

PAS domain

7 of 39

1.71

3.14

1.51e-09

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

5 of 28

1.71

2.43

8.74e-07

SM00448

cheY-homologous receiver domain

6 of 51

1.52

2.22

3.12e-07

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