BESB_039100 protein (Besnoitia besnoiti) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

Your Input:

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Score

BESB_039100

UDP-sugar pyrophospharylase. (616 aa)

Predicted Functional Partners:

BESB_060680

0.952

BESB_068080

0.917

BESB_044720

0.855

BESB_048000

0.817

BESB_072170

0.732

BESB_083020

0.705

BESB_063400

0.687

BESB_059690

0.671

BESB_067690

0.660

BESB_045080

0.653

Your Current Organism:

Besnoitia besnoiti

NCBI taxonomy Id: 94643
Other names: B. besnoiti

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BESB_039100	BESB_044720	A0A2A9MNY7	A0A2A9MLE6	UDP-sugar pyrophospharylase.	Glucosephosphate-mutase GPM2.	0.855
BESB_039100	BESB_045080	A0A2A9MNY7	A0A2A9MK19	UDP-sugar pyrophospharylase.	Uncharacterized protein.	0.653
BESB_039100	BESB_048000	A0A2A9MNY7	A0A2A9MDN0	UDP-sugar pyrophospharylase.	Phosphoacetylglucosamine mutase.	0.817
BESB_039100	BESB_059690	A0A2A9MNY7	A0A2A9MI59	UDP-sugar pyrophospharylase.	Amylo-alpha-1,6-glucosidase.	0.671
BESB_039100	BESB_060680	A0A2A9MNY7	A0A2A9MFY7	UDP-sugar pyrophospharylase.	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	0.952
BESB_039100	BESB_063400	A0A2A9MNY7	A0A2A9MII9	UDP-sugar pyrophospharylase.	Trehalose-phosphatase.	0.687
BESB_039100	BESB_067690	A0A2A9MNY7	A0A2A9MFJ9	UDP-sugar pyrophospharylase.	GDP-L-fucose synthetase.	0.660
BESB_039100	BESB_068080	A0A2A9MNY7	A0A2A9M9V8	UDP-sugar pyrophospharylase.	Glucosephosphate-mutase GPM1.	0.917
BESB_039100	BESB_072170	A0A2A9MNY7	A0A2A9M7U0	UDP-sugar pyrophospharylase.	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	0.732
BESB_039100	BESB_083020	A0A2A9MNY7	A0A2A9MBQ2	UDP-sugar pyrophospharylase.	GHMP kinase, N-terminal domain-containing protein.	0.705
BESB_044720	BESB_039100	A0A2A9MLE6	A0A2A9MNY7	Glucosephosphate-mutase GPM2.	UDP-sugar pyrophospharylase.	0.855
BESB_044720	BESB_045080	A0A2A9MLE6	A0A2A9MK19	Glucosephosphate-mutase GPM2.	Uncharacterized protein.	0.523
BESB_044720	BESB_048000	A0A2A9MLE6	A0A2A9MDN0	Glucosephosphate-mutase GPM2.	Phosphoacetylglucosamine mutase.	0.569
BESB_044720	BESB_059690	A0A2A9MLE6	A0A2A9MI59	Glucosephosphate-mutase GPM2.	Amylo-alpha-1,6-glucosidase.	0.788
BESB_044720	BESB_060680	A0A2A9MLE6	A0A2A9MFY7	Glucosephosphate-mutase GPM2.	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	0.653
BESB_044720	BESB_067690	A0A2A9MLE6	A0A2A9MFJ9	Glucosephosphate-mutase GPM2.	GDP-L-fucose synthetase.	0.769
BESB_044720	BESB_068080	A0A2A9MLE6	A0A2A9M9V8	Glucosephosphate-mutase GPM2.	Glucosephosphate-mutase GPM1.	0.942
BESB_044720	BESB_072170	A0A2A9MLE6	A0A2A9M7U0	Glucosephosphate-mutase GPM2.	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	0.876
BESB_044720	BESB_083020	A0A2A9MLE6	A0A2A9MBQ2	Glucosephosphate-mutase GPM2.	GHMP kinase, N-terminal domain-containing protein.	0.555
BESB_045080	BESB_039100	A0A2A9MK19	A0A2A9MNY7	Uncharacterized protein.	UDP-sugar pyrophospharylase.	0.653

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.715

expected number of edges:

36

PPI enrichment p-value:

0.514

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007186

G protein-coupled receptor signaling pathway

6 of 131

1.92

2.98

1.77e-07

GO:0048312

Intracellular distribution of mitochondria

2 of 4

2.96

1.53

0.0017

GO:1902115

Regulation of organelle assembly

3 of 50

2.04

1.48

0.0013

GO:1900242

Regulation of synaptic vesicle endocytosis

2 of 5

2.87

1.48

0.0021

GO:0007154

Cell communication

9 of 1248

1.12

1.33

1.51e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030159

Signaling receptor complex adaptor activity

3 of 22

2.4

1.78

0.00047

GO:0001965

G-protein alpha-subunit binding

2 of 5

2.87

1.38

0.0032

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

4 of 13

2.75

3.74

1.08e-07

GO:0044297

Cell body

2 of 26

2.15

1.18

0.0061

GO:0043195

Terminal bouton

2 of 23

2.2

1.18

0.0061

GO:0071944

Cell periphery

7 of 1721

0.87

0.74

0.00070

GO:0005770

Late endosome

2 of 83

1.65

0.69

0.0426

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10680

GPCR ligand binding, and Regulation of G protein-coupled receptor signaling pathway

7 of 75

2.23

5.07

1.03e-11

CL:10782

RGS domain, and GTPase complex

5 of 20

2.66

4.96

3.29e-10

CL:10783

RGS domain, and GTPase complex

4 of 13

2.75

4.01

3.19e-08

CL:344

Intracellular distribution of mitochondria, and Immunoglobulin V-set domain

2 of 5

2.87

1.57

0.0014

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-418594

G alpha (i) signalling events

6 of 83

2.12

4.03

1.67e-09

MAP-372790

Signaling by GPCR

7 of 156

1.92

3.73

7.50e-10

MAP-373080

Class B/2 (Secretin family receptors)

3 of 4

3.14

3.25

1.25e-06

MAP-202040

G-protein activation

3 of 4

3.14

3.25

1.25e-06

MAP-397795

G-protein beta:gamma signalling

3 of 7

2.9

3.09

2.14e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098562

Cytoplasmic side of membrane

5 of 27

2.53

4.37

3.37e-09

GOCC:0005834

Heterotrimeric G-protein complex

3 of 11

2.7

2.73

8.88e-06

GOCC:0032473

Cytoplasmic side of mitochondrial outer membrane

2 of 2

3.26

2.12

0.00015

GOCC:0071944

Cell periphery

8 of 696

1.32

1.87

1.07e-07

GOCC:0005886

Plasma membrane

7 of 614

1.32

1.68

1.90e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

3 of 130

1.63

0.96

0.0102

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016346

Guanine nucleotide-binding protein, beta subunit

3 of 3

3.26

2.84

7.33e-06

IPR001632

G-protein, beta subunit

2 of 2

3.26

1.45

0.0025

IPR019775

WD40 repeat, conserved site

3 of 65

1.93

1.14

0.0060

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

3 of 161

1.53

0.73

0.0327

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