RvY_05407-1 protein (Ramazzottius varieornatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

RvY_05407-1

Uncharacterized protein. (298 aa)

Predicted Functional Partners:

RvY_02986-1

0.992

RvY_02724-1

0.991

RvY_15740-1

0.989

RvY_10608-1

0.988

RvY_15596-1

0.986

RvY_17395-1

0.986

RvY_07746-1

0.982

RvY_12955-1

0.981

RvY_05849-1

0.979

RvY_04441-1

0.979

Your Current Organism:

Ramazzottius varieornatus

NCBI taxonomy Id: 947166
Other names: R. varieornatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RvY_02724-1	RvY_02986-1	A0A1D1UKQ1	A0A1D1UWQ8	Uncharacterized protein; Belongs to the universal ribosomal protein uL11 family.	Ribosomal_L16 domain-containing protein.	0.998
RvY_02724-1	RvY_04441-1	A0A1D1UKQ1	A0A1D1V1L3	Uncharacterized protein; Belongs to the universal ribosomal protein uL11 family.	Uncharacterized protein.	0.978
RvY_02724-1	RvY_05407-1	A0A1D1UKQ1	A0A1D1V0J6	Uncharacterized protein; Belongs to the universal ribosomal protein uL11 family.	Uncharacterized protein.	0.991
RvY_02724-1	RvY_05849-1	A0A1D1UKQ1	A0A1D1UZG2	Uncharacterized protein; Belongs to the universal ribosomal protein uL11 family.	RNase III domain-containing protein.	0.984
RvY_02724-1	RvY_07746-1	A0A1D1UKQ1	A0A1D1VCP6	Uncharacterized protein; Belongs to the universal ribosomal protein uL11 family.	Uncharacterized protein.	0.999
RvY_02724-1	RvY_10608-1	A0A1D1UKQ1	A0A1D1VFE3	Uncharacterized protein; Belongs to the universal ribosomal protein uL11 family.	Uncharacterized protein.	0.999
RvY_02724-1	RvY_12955-1	A0A1D1UKQ1	A0A1D1VN73	Uncharacterized protein; Belongs to the universal ribosomal protein uL11 family.	Uncharacterized protein.	0.997
RvY_02724-1	RvY_15596-1	A0A1D1UKQ1	A0A1D1VX08	Uncharacterized protein; Belongs to the universal ribosomal protein uL11 family.	Uncharacterized protein.	0.985
RvY_02724-1	RvY_15740-1	A0A1D1UKQ1	A0A1D1VVZ6	Uncharacterized protein; Belongs to the universal ribosomal protein uL11 family.	Uncharacterized protein.	0.994
RvY_02724-1	RvY_17395-1	A0A1D1UKQ1	A0A1D1W2T5	Uncharacterized protein; Belongs to the universal ribosomal protein uL11 family.	Uncharacterized protein.	0.999
RvY_02986-1	RvY_02724-1	A0A1D1UWQ8	A0A1D1UKQ1	Ribosomal_L16 domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uL11 family.	0.998
RvY_02986-1	RvY_04441-1	A0A1D1UWQ8	A0A1D1V1L3	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.996
RvY_02986-1	RvY_05407-1	A0A1D1UWQ8	A0A1D1V0J6	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.992
RvY_02986-1	RvY_05849-1	A0A1D1UWQ8	A0A1D1UZG2	Ribosomal_L16 domain-containing protein.	RNase III domain-containing protein.	0.993
RvY_02986-1	RvY_07746-1	A0A1D1UWQ8	A0A1D1VCP6	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.999
RvY_02986-1	RvY_10608-1	A0A1D1UWQ8	A0A1D1VFE3	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.999
RvY_02986-1	RvY_12955-1	A0A1D1UWQ8	A0A1D1VN73	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.995
RvY_02986-1	RvY_15596-1	A0A1D1UWQ8	A0A1D1VX08	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.989
RvY_02986-1	RvY_15740-1	A0A1D1UWQ8	A0A1D1VVZ6	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.992
RvY_02986-1	RvY_17395-1	A0A1D1UWQ8	A0A1D1W2T5	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.998

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.933

expected number of edges:

17

PPI enrichment p-value:

0.157

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0022900

Electron transport chain

8 of 58

1.98

4.42

1.20e-11

GO:0006120

Mitochondrial electron transport, NADH to ubiquinone

4 of 8

2.53

3.21

8.10e-07

GO:0019646

Aerobic electron transport chain

5 of 30

2.06

2.89

8.10e-07

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

5 of 31

2.04

2.88

8.10e-07

GO:0032981

Mitochondrial respiratory chain complex I assembly

3 of 16

2.11

1.65

0.00062

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008137

NADH dehydrogenase (ubiquinone) activity

7 of 20

2.38

5.8

7.60e-13

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

8 of 35

2.19

5.66

1.31e-13

GO:0009055

Electron transfer activity

8 of 56

1.99

4.8

7.95e-13

GO:0051539

4 iron, 4 sulfur cluster binding

3 of 38

1.73

1.25

0.0025

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005747

Mitochondrial respiratory chain complex I

9 of 19

2.51

8.72

2.85e-19

GO:1902495

Transmembrane transporter complex

10 of 33

2.32

8.15

1.05e-19

GO:0005746

Mitochondrial respirasome

10 of 39

2.24

7.75

1.79e-19

GO:0098803

Respiratory chain complex

10 of 40

2.23

7.7

1.79e-19

GO:1990204

Oxidoreductase complex

10 of 54

2.1

6.86

9.19e-19

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6225

NADH dehydrogenase complex

9 of 15

2.61

9.05

2.43e-19

CL:6213

NADH dehydrogenase complex, and NADH dehydrogenase (quinone) activity

10 of 34

2.3

7.97

2.43e-19

CL:6227

NADH dehydrogenase complex

6 of 8

2.71

6.47

3.04e-13

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

10 of 114

1.78

4.57

1.64e-15

map01100

Metabolic pathways

11 of 1992

0.58

0.51

3.43e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6799198

Complex I biogenesis

9 of 31

2.3

7.24

3.15e-17

MAP-611105

Respiratory electron transport

10 of 61

2.05

6.23

2.82e-17

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

10 of 72

1.98

5.84

4.35e-17

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

10 of 134

1.71

4.11

1.16e-14

MAP-1430728

Metabolism

10 of 1389

0.69

0.61

7.85e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

6 of 51

1.91

3.11

6.05e-08

GOCC:0005743

Mitochondrial inner membrane

6 of 154

1.43

1.73

9.59e-06

GOCC:0005746

Mitochondrial respirasome

3 of 22

1.97

1.65

0.00049

GOCC:0031966

Mitochondrial membrane

7 of 234

1.31

1.61

4.37e-06

GOCC:0098803

Respiratory chain complex

3 of 25

1.91

1.58

0.00064

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0830

Ubiquinone

7 of 33

2.16

5.02

5.25e-12

KW-0679

Respiratory chain

2 of 4

2.53

1.35

0.0034

KW-1278

Translocase

2 of 18

1.88

0.92

0.0172

KW-0813

Transport

4 of 202

1.13

0.75

0.0100

KW-0999

Mitochondrion inner membrane

2 of 33

1.62

0.68

0.0445

(more ...)

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