RvY_08492-1 protein (Ramazzottius varieornatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

RvY_08492-1

Uncharacterized protein. (123 aa)

Predicted Functional Partners:

RvY_00677-1

0.999

RvY_00579-1

0.999

RvY_01605-1

0.999

RvY_01330-1

0.999

RvY_01600-1

0.999

RvY_00120-2

0.999

RvY_00564-1

0.999

RvY_00639-1

0.999

RvY_02417-1

0.999

RvY_02479-1

0.999

Your Current Organism:

Ramazzottius varieornatus

NCBI taxonomy Id: 947166
Other names: R. varieornatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RvY_00120-2	RvY_00564-1	A0A1D1UM71	A0A1D1UN41	Uncharacterized protein.	Ubiquitin-like domain-containing protein.	0.999
RvY_00120-2	RvY_00579-1	A0A1D1UM71	A0A1D1UE73	Uncharacterized protein.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.999
RvY_00120-2	RvY_00639-1	A0A1D1UM71	A0A1D1UNA8	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_00120-2	RvY_00677-1	A0A1D1UM71	A0A1D1UDM4	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_00120-2	RvY_01330-1	A0A1D1UM71	A0A1D1UJI4	Uncharacterized protein.	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family.	0.999
RvY_00120-2	RvY_01600-1	A0A1D1UM71	A0A1D1UKC5	Uncharacterized protein.	Ribosomal_L16 domain-containing protein.	0.999
RvY_00120-2	RvY_01605-1	A0A1D1UM71	A0A1D1UH63	Uncharacterized protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.999
RvY_00120-2	RvY_02417-1	A0A1D1UM71	A0A1D1UNE0	Uncharacterized protein.	60S ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.	0.999
RvY_00120-2	RvY_02479-1	A0A1D1UM71	A0A1D1UNL0	Uncharacterized protein.	Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL42 family.	0.999
RvY_00120-2	RvY_08492-1	A0A1D1UM71	A0A1D1V8A6	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_00564-1	RvY_00120-2	A0A1D1UN41	A0A1D1UM71	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.999
RvY_00564-1	RvY_00579-1	A0A1D1UN41	A0A1D1UE73	Ubiquitin-like domain-containing protein.	S5 DRBM domain-containing protein; Belongs to the universal ribosomal protein uS5 family.	0.999
RvY_00564-1	RvY_00639-1	A0A1D1UN41	A0A1D1UNA8	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.999
RvY_00564-1	RvY_00677-1	A0A1D1UN41	A0A1D1UDM4	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.999
RvY_00564-1	RvY_01330-1	A0A1D1UN41	A0A1D1UJI4	Ubiquitin-like domain-containing protein.	40S ribosomal protein S25; Belongs to the eukaryotic ribosomal protein eS25 family.	0.999
RvY_00564-1	RvY_01600-1	A0A1D1UN41	A0A1D1UKC5	Ubiquitin-like domain-containing protein.	Ribosomal_L16 domain-containing protein.	0.999
RvY_00564-1	RvY_01605-1	A0A1D1UN41	A0A1D1UH63	Ubiquitin-like domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS9 family.	0.999
RvY_00564-1	RvY_02417-1	A0A1D1UN41	A0A1D1UNE0	Ubiquitin-like domain-containing protein.	60S ribosomal protein L18a; Belongs to the eukaryotic ribosomal protein eL20 family.	0.999
RvY_00564-1	RvY_02479-1	A0A1D1UN41	A0A1D1UNL0	Ubiquitin-like domain-containing protein.	Uncharacterized protein; Belongs to the eukaryotic ribosomal protein eL42 family.	0.999
RvY_00564-1	RvY_08492-1	A0A1D1UN41	A0A1D1V8A6	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.859

expected number of edges:

11

PPI enrichment p-value:

0.00603

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015849

Organic acid transport

8 of 125

1.51

2.42

1.92e-08

GO:0071702

Organic substance transport

10 of 427

1.07

1.35

5.89e-08

GO:0055085

Transmembrane transport

11 of 739

0.88

0.96

1.18e-07

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042803

Protein homodimerization activity

8 of 14

2.46

7.04

1.93e-15

GO:0043177

Organic acid binding

8 of 33

2.09

5.34

1.43e-13

GO:0046872

Metal ion binding

8 of 643

0.8

0.67

0.00056

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031317

Tripartite ATP-independent periplasmic transporter complex

8 of 10

2.61

8.05

4.62e-17

GO:0042597

Periplasmic space

8 of 259

1.19

1.56

1.80e-07

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9764

Tripartite ATP-independent periplasmic transporter complex, and TRAP transporter large membrane protein DctM

11 of 27

2.32

8.92

3.74e-22

CL:9765

Tripartite ATP-independent periplasmic transporter complex, and TRAP transporter large membrane protein DctM

10 of 22

2.36

8.5

3.71e-20

CL:9766

Solute binding protein, TakP-like, and TRAP transporter large membrane protein DctM

5 of 13

2.29

3.82

1.84e-08

CL:9792

Tripartite ATP-independent periplasmic transporter complex, and TRAP transporter large membrane protein DctM

4 of 6

2.53

3.42

3.10e-07

CL:9768

Solute binding protein, TakP-like, and TRAP transporter large membrane protein DctM

4 of 7

2.46

3.32

4.26e-07

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031317

Tripartite ATP-independent periplasmic transporter complex

8 of 32

2.1

5.36

1.72e-13

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0675

Receptor

7 of 31

2.06

4.52

2.77e-11

KW-0574

Periplasm

5 of 15

2.23

3.76

1.78e-08

KW-0732

Signal

7 of 541

0.82

0.65

0.0015

KW-0479

Metal-binding

5 of 305

0.92

0.62

0.0102

KW-0813

Transport

5 of 347

0.86

0.56

0.0148

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF03480

Bacterial extracellular solute-binding protein, family 7

8 of 36

2.05

4.97

9.25e-13

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038404

TRAP transporter solute receptor DctP superfamily

8 of 30

2.13

5.26

6.16e-13

IPR018389

TRAP transporter solute receptor DctP

8 of 30

2.13

5.26

6.16e-13

IPR026289

Solute binding protein, TakP-like

5 of 6

2.63

4.47

2.84e-09

IPR006311

Twin-arginine translocation pathway, signal sequence

5 of 55

1.66

1.94

2.41e-05

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