RvY_12848-1 protein (Ramazzottius varieornatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

RvY_12848-1

DOMON domain-containing protein. (191 aa)

Predicted Functional Partners:

RvY_03641-1

0.727

RvY_09206-1

0.727

RvY_07746-1

0.700

RvY_09974-1

0.690

RvY_13150-1

0.684

RvY_02986-1

0.682

RvY_17395-1

0.681

RvY_10608-1

0.677

RvY_01352-1

0.675

RvY_10237-1

0.669

Your Current Organism:

Ramazzottius varieornatus

NCBI taxonomy Id: 947166
Other names: R. varieornatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RvY_01352-1	RvY_02986-1	A0A1D1UGX7	A0A1D1UWQ8	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Ribosomal_L16 domain-containing protein.	0.999
RvY_01352-1	RvY_03641-1	A0A1D1UGX7	A0A1D1UYX8	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Nudix hydrolase domain-containing protein.	0.998
RvY_01352-1	RvY_07746-1	A0A1D1UGX7	A0A1D1VCP6	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Uncharacterized protein.	0.998
RvY_01352-1	RvY_09206-1	A0A1D1UGX7	A0A1D1V8H6	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Uncharacterized protein.	0.994
RvY_01352-1	RvY_09974-1	A0A1D1UGX7	A0A1D1VFP5	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Uncharacterized protein.	0.999
RvY_01352-1	RvY_10237-1	A0A1D1UGX7	A0A1D1VC46	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Uncharacterized protein.	0.995
RvY_01352-1	RvY_10608-1	A0A1D1UGX7	A0A1D1VFE3	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Uncharacterized protein.	0.999
RvY_01352-1	RvY_12848-1	A0A1D1UGX7	A0A1D1VKW8	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	DOMON domain-containing protein.	0.675
RvY_01352-1	RvY_13150-1	A0A1D1UGX7	A0A1D1VVH6	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Uncharacterized protein; Belongs to the universal ribosomal protein uL22 family.	0.998
RvY_01352-1	RvY_17395-1	A0A1D1UGX7	A0A1D1W2T5	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	Uncharacterized protein.	0.999
RvY_02986-1	RvY_01352-1	A0A1D1UWQ8	A0A1D1UGX7	Ribosomal_L16 domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uS15 family.	0.999
RvY_02986-1	RvY_03641-1	A0A1D1UWQ8	A0A1D1UYX8	Ribosomal_L16 domain-containing protein.	Nudix hydrolase domain-containing protein.	0.998
RvY_02986-1	RvY_07746-1	A0A1D1UWQ8	A0A1D1VCP6	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.999
RvY_02986-1	RvY_09206-1	A0A1D1UWQ8	A0A1D1V8H6	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.994
RvY_02986-1	RvY_09974-1	A0A1D1UWQ8	A0A1D1VFP5	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.998
RvY_02986-1	RvY_10237-1	A0A1D1UWQ8	A0A1D1VC46	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.994
RvY_02986-1	RvY_10608-1	A0A1D1UWQ8	A0A1D1VFE3	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.999
RvY_02986-1	RvY_12848-1	A0A1D1UWQ8	A0A1D1VKW8	Ribosomal_L16 domain-containing protein.	DOMON domain-containing protein.	0.682
RvY_02986-1	RvY_13150-1	A0A1D1UWQ8	A0A1D1VVH6	Ribosomal_L16 domain-containing protein.	Uncharacterized protein; Belongs to the universal ribosomal protein uL22 family.	0.999
RvY_02986-1	RvY_17395-1	A0A1D1UWQ8	A0A1D1W2T5	Ribosomal_L16 domain-containing protein.	Uncharacterized protein.	0.998

page 1 of 6

Network Stats

number of nodes:

10

number of edges:

23

average node degree:

4.6

avg. local clustering coefficient:

0.815

expected number of edges:

9

PPI enrichment p-value:

8.66e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:6148

IBR domain, and Fucose metabolism

2 of 6

2.89

1.56

0.0015

CL:5896

14-3-3 domain, and RAF activation

2 of 5

2.97

1.56

0.0015

CL:3521

LAG1, DNA binding, and Protein of unknown function DUF6699

2 of 5

2.97

1.56

0.0015

CL:5882

Mixed, incl. Protein kinase domain, and Non-membrane spanning protein tyrosine kinase activity

4 of 162

1.76

1.36

0.0015

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03050

Proteasome

2 of 49

1.98

0.79

0.0330

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-109606

Intrinsic Pathway for Apoptosis

2 of 7

2.82

1.24

0.0057

MAP-75035

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex

2 of 13

2.55

1.23

0.0057

MAP-5625740

RHO GTPases activate PKNs

2 of 10

2.67

1.23

0.0057

MAP-109581

Apoptosis

2 of 23

2.3

1.04

0.0118

MAP-5357801

Programmed Cell Death

2 of 35

2.12

0.9

0.0209

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR040159

Suppressor of hairless-like

2 of 2

3.37

1.39

0.0032

IPR037095

RBP-J/Cbf11, DNA binding domain superfamily

2 of 2

3.37

1.39

0.0032

IPR036815

14-3-3 domain superfamily

2 of 2

3.37

1.39

0.0032

IPR036358

Beta-trefoil domain superfamily

2 of 2

3.37

1.39

0.0032

IPR023410

14-3-3 domain

2 of 2

3.37

1.39

0.0032

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01268

Beta-trefoil DNA-binding domain

2 of 2

3.37

1.93

0.00034

SM01267

LAG1, DNA binding

2 of 2

3.37

1.93

0.00034

SM00101

14-3-3 homologues

2 of 2

3.37

1.93

0.00034

SM00248

Ankyrin repeats

2 of 67

1.84

0.77

0.0327

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