RvY_14128-1 protein (Ramazzottius varieornatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

RvY_14128-1

Uncharacterized protein. (613 aa)

Predicted Functional Partners:

RvY_18528-1

0.695

RvY_15939-1

0.668

RvY_12012-1

0.655

RvY_14542-1

0.654

RvY_16379-1

0.654

RvY_14979-1

0.634

RvY_05079-1

0.625

RvY_17849-1

0.622

RvY_12013-1

0.608

RvY_15835-1

0.569

Your Current Organism:

Ramazzottius varieornatus

NCBI taxonomy Id: 947166
Other names: R. varieornatus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RvY_05079-1	RvY_14128-1	A0A1D1UUE9	A0A1D1VQ97	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.625
RvY_05079-1	RvY_14542-1	A0A1D1UUE9	A0A1D1VTE2	Uncharacterized protein; Belongs to the DEAD box helicase family.	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	0.910
RvY_05079-1	RvY_15939-1	A0A1D1UUE9	A0A1D1VY34	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.434
RvY_05079-1	RvY_16379-1	A0A1D1UUE9	A0A1D1VY90	Uncharacterized protein; Belongs to the DEAD box helicase family.	RRM domain-containing protein.	0.871
RvY_05079-1	RvY_17849-1	A0A1D1UUE9	A0A1D1W7A0	Uncharacterized protein; Belongs to the DEAD box helicase family.	Uncharacterized protein.	0.434
RvY_12012-1	RvY_14128-1	A0A1D1VI17	A0A1D1VQ97	Uncharacterized protein.	Uncharacterized protein.	0.655
RvY_12013-1	RvY_14128-1	A0A1D1VKF3	A0A1D1VQ97	Uncharacterized protein.	Uncharacterized protein.	0.608
RvY_14128-1	RvY_05079-1	A0A1D1VQ97	A0A1D1UUE9	Uncharacterized protein.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.625
RvY_14128-1	RvY_12012-1	A0A1D1VQ97	A0A1D1VI17	Uncharacterized protein.	Uncharacterized protein.	0.655
RvY_14128-1	RvY_12013-1	A0A1D1VQ97	A0A1D1VKF3	Uncharacterized protein.	Uncharacterized protein.	0.608
RvY_14128-1	RvY_14542-1	A0A1D1VQ97	A0A1D1VTE2	Uncharacterized protein.	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	0.654
RvY_14128-1	RvY_14979-1	A0A1D1VQ97	A0A1D1VT80	Uncharacterized protein.	Uncharacterized protein.	0.634
RvY_14128-1	RvY_15835-1	A0A1D1VQ97	A0A1D1VWC2	Uncharacterized protein.	Uncharacterized protein.	0.569
RvY_14128-1	RvY_15939-1	A0A1D1VQ97	A0A1D1VY34	Uncharacterized protein.	Uncharacterized protein.	0.668
RvY_14128-1	RvY_16379-1	A0A1D1VQ97	A0A1D1VY90	Uncharacterized protein.	RRM domain-containing protein.	0.654
RvY_14128-1	RvY_17849-1	A0A1D1VQ97	A0A1D1W7A0	Uncharacterized protein.	Uncharacterized protein.	0.622
RvY_14128-1	RvY_18528-1	A0A1D1VQ97	A0A1D1WAK4	Uncharacterized protein.	ATR; Belongs to the PI3/PI4-kinase family.	0.695
RvY_14542-1	RvY_05079-1	A0A1D1VTE2	A0A1D1UUE9	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	Uncharacterized protein; Belongs to the DEAD box helicase family.	0.910
RvY_14542-1	RvY_14128-1	A0A1D1VTE2	A0A1D1VQ97	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	Uncharacterized protein.	0.654
RvY_14542-1	RvY_15939-1	A0A1D1VTE2	A0A1D1VY34	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family.	Uncharacterized protein.	0.719

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Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.781

expected number of edges:

11

PPI enrichment p-value:

0.00014

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000096

Sulfur amino acid metabolic process

6 of 18

1.99

3.28

4.67e-08

GO:0000097

Sulfur amino acid biosynthetic process

5 of 13

2.05

2.89

7.98e-07

GO:0006534

Cysteine metabolic process

4 of 9

2.11

2.39

1.56e-05

GO:1901607

Alpha-amino acid biosynthetic process

6 of 103

1.23

1.27

8.95e-05

GO:1901605

Alpha-amino acid metabolic process

7 of 147

1.14

1.21

3.34e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030170

Pyridoxal phosphate binding

4 of 28

1.62

1.28

0.0016

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2328

Cysteine and methionine metabolism, and L-serine metabolic process

5 of 20

1.86

2.47

3.00e-06

CL:2329

Cys/Met metabolism, pyridoxal phosphate-dependent enzyme, and Cysteine and methionine metabolism

4 of 11

2.02

2.31

1.79e-05

CL:2332

Sulfur amino acid biosynthetic process, and Potassium

3 of 5

2.24

1.93

0.00020

CL:2257

Glycine, serine and threonine metabolism, and Sulfur amino acid metabolic process

6 of 64

1.44

1.76

8.74e-06

CL:2105

Alpha-amino acid metabolic process, and Glycine, serine and threonine metabolism

8 of 140

1.22

1.5

1.77e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00270

Cysteine and methionine metabolism

8 of 41

1.75

3.65

3.23e-11

map01230

Biosynthesis of amino acids

8 of 154

1.18

1.5

3.21e-07

map00450

Selenocompound metabolism

3 of 18

1.69

1.4

0.00096

map00920

Sulfur metabolism

3 of 38

1.36

0.94

0.0062

map00260

Glycine, serine and threonine metabolism

3 of 67

1.11

0.63

0.0258

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00291

Pyridoxal-phosphate dependent enzyme

3 of 5

2.24

1.65

0.00074

PF01842

ACT domain

2 of 5

2.07

0.7

0.0497

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001926

Tryptophan synthase beta chain-like, PALP domain

3 of 5

2.24

1.42

0.0021

IPR036052

Tryptophan synthase beta chain-like, PALP domain superfamily

3 of 6

2.16

1.41

0.0021

IPR001216

Cysteine synthase/cystathionine beta-synthase, pyridoxal-phosphate attachment site

2 of 2

2.46

0.86

0.0265

IPR015422

Pyridoxal phosphate-dependent transferase, small domain

3 of 25

1.54

0.75

0.0291

IPR015424

Pyridoxal phosphate-dependent transferase

3 of 27

1.51

0.74

0.0291

(more ...)

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