RvY_17786-1 protein (Ramazzottius varieornatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

RvY_17786-1

Uncharacterized protein. (1515 aa)

Predicted Functional Partners:

RvY_02634-1

0.999

RvY_07468-1

0.999

RvY_09016-1

0.999

RvY_09065-1

0.999

RvY_13496-1

0.999

RvY_14355-1

0.999

RvY_15634-1

0.999

RvY_12912-1

0.996

RvY_09610-1

0.995

RvY_09227-1

0.992

Your Current Organism:

Ramazzottius varieornatus

NCBI taxonomy Id: 947166
Other names: R. varieornatus

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... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RvY_02634-1	RvY_07468-1	A0A1D1UKE7	A0A1D1V7B9	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_02634-1	RvY_09016-1	A0A1D1UKE7	A0A1D1VA59	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_02634-1	RvY_09065-1	A0A1D1UKE7	A0A1D1VAJ1	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_02634-1	RvY_09227-1	A0A1D1UKE7	A0A1D1VGJ3	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.996
RvY_02634-1	RvY_09610-1	A0A1D1UKE7	A0A1D1VC44	Uncharacterized protein.	Uncharacterized protein.	0.985
RvY_02634-1	RvY_12912-1	A0A1D1UKE7	A0A1D1VUQ7	Uncharacterized protein.	Uncharacterized protein.	0.996
RvY_02634-1	RvY_13496-1	A0A1D1UKE7	A0A1D1VN40	Uncharacterized protein.	SKIP_SNW domain-containing protein.	0.999
RvY_02634-1	RvY_14355-1	A0A1D1UKE7	A0A1D1VQZ9	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_02634-1	RvY_15634-1	A0A1D1UKE7	A0A1D1VYS7	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_02634-1	RvY_17786-1	A0A1D1UKE7	A0A1D1W720	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_07468-1	RvY_02634-1	A0A1D1V7B9	A0A1D1UKE7	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_07468-1	RvY_09016-1	A0A1D1V7B9	A0A1D1VA59	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_07468-1	RvY_09065-1	A0A1D1V7B9	A0A1D1VAJ1	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_07468-1	RvY_09227-1	A0A1D1V7B9	A0A1D1VGJ3	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.996
RvY_07468-1	RvY_09610-1	A0A1D1V7B9	A0A1D1VC44	Uncharacterized protein.	Uncharacterized protein.	0.992
RvY_07468-1	RvY_12912-1	A0A1D1V7B9	A0A1D1VUQ7	Uncharacterized protein.	Uncharacterized protein.	0.997
RvY_07468-1	RvY_13496-1	A0A1D1V7B9	A0A1D1VN40	Uncharacterized protein.	SKIP_SNW domain-containing protein.	0.999
RvY_07468-1	RvY_14355-1	A0A1D1V7B9	A0A1D1VQZ9	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_07468-1	RvY_15634-1	A0A1D1V7B9	A0A1D1VYS7	Uncharacterized protein.	Uncharacterized protein.	0.999
RvY_07468-1	RvY_17786-1	A0A1D1V7B9	A0A1D1W720	Uncharacterized protein.	Uncharacterized protein.	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

28

average node degree:

5.09

avg. local clustering coefficient:

0.85

expected number of edges:

13

PPI enrichment p-value:

0.000158

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042274

Ribosomal small subunit biogenesis

6 of 74

1.88

3.17

3.12e-08

GO:0006364

rRNA processing

9 of 212

1.6

3.04

1.34e-10

GO:0030490

Maturation of SSU-rRNA

5 of 59

1.9

2.72

7.97e-07

GO:0000462

Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

4 of 44

1.93

2.2

2.23e-05

GO:0016070

RNA metabolic process

10 of 794

1.07

1.36

3.12e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030515

snoRNA binding

3 of 23

2.09

1.31

0.0032

GO:0003723

RNA binding

6 of 541

1.02

0.74

0.0054

GO:0003676

Nucleic acid binding

7 of 1267

0.72

0.41

0.0410

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032040

Small-subunit processome

8 of 54

2.14

5.52

1.31e-13

GO:0034455

t-UTP complex

3 of 4

2.85

3.0

3.02e-06

GO:0005730

Nucleolus

8 of 244

1.49

2.47

4.41e-09

GO:0043232

Intracellular non-membrane-bounded organelle

10 of 1009

0.97

1.12

1.59e-07

GO:0030686

90S preribosome

2 of 37

1.71

0.74

0.0360

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7255

Small-subunit processome, and U3 snoRNA binding

8 of 51

2.17

5.55

1.72e-13

CL:7265

snoRNA binding, and Pwp2p-containing subcomplex of 90S preribosome

5 of 18

2.42

4.32

2.70e-09

CL:7280

t-UTP complex

4 of 5

2.88

4.27

1.23e-08

CL:7324

Small-subunit processome, and Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type

3 of 14

2.3

2.18

6.71e-05

CL:6690

Cytosolic small ribosomal subunit, and Ribosomal protein S8

2 of 22

1.93

0.81

0.0291

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

6 of 92

1.79

2.96

4.00e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

10 of 146

1.81

4.63

4.46e-15

MAP-8868773

rRNA processing in the nucleus and cytosol

10 of 149

1.8

4.59

4.46e-15

MAP-72312

rRNA processing

10 of 152

1.79

4.55

4.46e-15

MAP-8953854

Metabolism of RNA

10 of 586

1.21

1.77

8.82e-10

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032040

Small-subunit processome

4 of 19

2.3

2.7

5.55e-06

GOCC:0034455

t-UTP complex

2 of 3

2.8

1.44

0.0024

GOCC:1990904

Ribonucleoprotein complex

7 of 407

1.21

1.34

2.05e-05

GOCC:0005730

Nucleolus

3 of 105

1.43

0.79

0.0197

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 28

1.83

0.71

0.0448

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

4 of 114

1.52

1.28

0.0011

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001680

WD40 repeat

4 of 121

1.49

0.84

0.0163

IPR015943

WD40/YVTN repeat-like-containing domain superfamily

4 of 155

1.38

0.76

0.0212

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

4 of 130

1.46

1.12

0.0026

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