Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ERBB2Receptor protein-tyrosine kinase. (1255 aa)    
Predicted Functional Partners:
ERBB4
Receptor protein-tyrosine kinase.
  
0.999
EGF
Pro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6.
   
 0.997
NRG1
Neuregulin 1.
    
 0.997
SHC1
SHC-transforming protein 1 isoform 3.
    
 0.997
ERBB3
Receptor tyrosine-protein kinase erbB-3 isoform 1.
  
0.997
GRB2
Growth factor receptor-bound protein 2 isoform 1.
    
 0.996
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
    
 0.995
PIK3R1
Phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1.
    
 0.995
SRC
Tyrosine-protein kinase.
  
 
0.995
EGFR
Receptor protein-tyrosine kinase.
  
 
0.995
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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