Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MACC1MET transcriptional regulator MACC1. (827 aa)    
Predicted Functional Partners:
DNMBP
Dynamin-binding protein.
      
 0.731
MDC1
Mediator of DNA damage checkpoint 1.
      
 0.676
SIX3
SIX homeobox 3.
      
 0.582
RRS1
Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.
      
 0.582
ENSCJAP00000072730
Uncharacterized protein.
      
 0.582
MET
Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]
    
 
 0.571
ITGA6
Integrin subunit alpha 6; Belongs to the integrin alpha chain family.
   
    0.536
EPS15
Epidermal growth factor receptor substrate 15 isoform A.
   
 
 0.486
PAXIP1
PAX interacting protein 1.
      
 0.482
LAMTOR2
Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.
     
 0.452
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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