SHC4 protein (Callithrix jacchus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SHC4

SHC adaptor protein 4. (627 aa)

Predicted Functional Partners:

EGFR

0.976

MET

0.970

GRB2

0.969

ERBB2

0.968

ERBB3

0.968

ERBB4

0.968

GAB1

0.967

IGF1R

0.956

INSR

0.956

FGFR3

0.938

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EGFR	ERBB2	ENSCJAP00000074658	ENSCJAP00000001808	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.998
EGFR	ERBB3	ENSCJAP00000074658	ENSCJAP00000022152	Receptor protein-tyrosine kinase.	Receptor tyrosine-protein kinase erbB-3 isoform 1.	0.992
EGFR	ERBB4	ENSCJAP00000074658	ENSCJAP00000069390	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.915
EGFR	FGFR3	ENSCJAP00000074658	ENSCJAP00000059324	Receptor protein-tyrosine kinase.	Fibroblast growth factor receptor.	0.488
EGFR	GAB1	ENSCJAP00000074658	ENSCJAP00000005121	Receptor protein-tyrosine kinase.	GRB2 associated binding protein 1.	0.994
EGFR	GRB2	ENSCJAP00000074658	ENSCJAP00000067776	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2 isoform 1.	0.999
EGFR	IGF1R	ENSCJAP00000074658	ENSCJAP00000011684	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.802
EGFR	INSR	ENSCJAP00000074658	ENSCJAP00000053402	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.459
EGFR	MET	ENSCJAP00000074658	ENSCJAP00000009442	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.940
EGFR	SHC4	ENSCJAP00000074658	ENSCJAP00000003029	Receptor protein-tyrosine kinase.	SHC adaptor protein 4.	0.976
ERBB2	EGFR	ENSCJAP00000001808	ENSCJAP00000074658	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.998
ERBB2	ERBB3	ENSCJAP00000001808	ENSCJAP00000022152	Receptor protein-tyrosine kinase.	Receptor tyrosine-protein kinase erbB-3 isoform 1.	0.999
ERBB2	ERBB4	ENSCJAP00000001808	ENSCJAP00000069390	Receptor protein-tyrosine kinase.	Receptor protein-tyrosine kinase.	0.994
ERBB2	FGFR3	ENSCJAP00000001808	ENSCJAP00000059324	Receptor protein-tyrosine kinase.	Fibroblast growth factor receptor.	0.499
ERBB2	GAB1	ENSCJAP00000001808	ENSCJAP00000005121	Receptor protein-tyrosine kinase.	GRB2 associated binding protein 1.	0.970
ERBB2	GRB2	ENSCJAP00000001808	ENSCJAP00000067776	Receptor protein-tyrosine kinase.	Growth factor receptor-bound protein 2 isoform 1.	0.995
ERBB2	IGF1R	ENSCJAP00000001808	ENSCJAP00000011684	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.819
ERBB2	INSR	ENSCJAP00000001808	ENSCJAP00000053402	Receptor protein-tyrosine kinase.	Tyrosine-protein kinase receptor.	0.561
ERBB2	MET	ENSCJAP00000001808	ENSCJAP00000009442	Receptor protein-tyrosine kinase.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.820
ERBB2	SHC4	ENSCJAP00000001808	ENSCJAP00000003029	Receptor protein-tyrosine kinase.	SHC adaptor protein 4.	0.968