Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MMEL1Membrane metalloendopeptidase like 1. (777 aa)    
Predicted Functional Partners:
IDE
Insulin-degrading enzyme isoform 1; Belongs to the peptidase M16 family.
   
  
 0.947
AGT
Angiotensin 1-4; Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. [Angiotensin-3]: stimulates aldosterone release. Belongs to the serpin family.
    
 0.891
ENSCJAP00000076309
Angiotensin-converting enzyme.
   
  
 0.781
PSEN1
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
  
 0.734
ACE
Angiotensin-converting enzyme.
   
  
 0.730
ADAM10
Disintegrin and metalloproteinase domain-containing protein 10.
    
 
 0.729
BACE1
Beta-secretase 1 isoform A preproprotein; Belongs to the peptidase A1 family.
      
 0.728
PSEN2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
  
 0.654
EDN1
Endothelin-1 isoform 1 preproprotein.
     
 0.645
NR3C2
Uncharacterized protein.
      
 0.642
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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