MYBPHL protein (Callithrix jacchus) - STRING interaction network

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

MYBPHL

Myosin binding protein H like. (354 aa)

Predicted Functional Partners:

MYL7

0.671

AMHR2

0.616

CASP8AP2

0.504

PRPF19

0.497

TACC2

0.497

CCS

0.495

PSMB4

0.491

PSRC1

0.476

RHEBL1

0.452

NPPA

0.449

Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMHR2	CCS	ENSCJAP00000034489	ENSCJAP00000002298	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	Copper chaperone for superoxide dismutase.	0.515
AMHR2	MYBPHL	ENSCJAP00000034489	ENSCJAP00000005355	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	Myosin binding protein H like.	0.616
AMHR2	PRPF19	ENSCJAP00000034489	ENSCJAP00000030447	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	Pre-mRNA-processing factor 19.	0.547
AMHR2	PSMB4	ENSCJAP00000034489	ENSCJAP00000014051	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.537
AMHR2	RHEBL1	ENSCJAP00000034489	ENSCJAP00000038803	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	GTPase RhebL1.	0.653
AMHR2	TACC2	ENSCJAP00000034489	ENSCJAP00000070046	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	Transforming acidic coiled-coil containing protein 2.	0.599
CASP8AP2	MYBPHL	ENSCJAP00000070606	ENSCJAP00000005355	Caspase 8 associated protein 2.	Myosin binding protein H like.	0.504
CCS	AMHR2	ENSCJAP00000002298	ENSCJAP00000034489	Copper chaperone for superoxide dismutase.	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	0.515
CCS	MYBPHL	ENSCJAP00000002298	ENSCJAP00000005355	Copper chaperone for superoxide dismutase.	Myosin binding protein H like.	0.495
CCS	PRPF19	ENSCJAP00000002298	ENSCJAP00000030447	Copper chaperone for superoxide dismutase.	Pre-mRNA-processing factor 19.	0.569
CCS	PSMB4	ENSCJAP00000002298	ENSCJAP00000014051	Copper chaperone for superoxide dismutase.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.515
CCS	RHEBL1	ENSCJAP00000002298	ENSCJAP00000038803	Copper chaperone for superoxide dismutase.	GTPase RhebL1.	0.402
MYBPHL	AMHR2	ENSCJAP00000005355	ENSCJAP00000034489	Myosin binding protein H like.	Anti-Muellerian hormone type-2 receptor; On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.	0.616
MYBPHL	CASP8AP2	ENSCJAP00000005355	ENSCJAP00000070606	Myosin binding protein H like.	Caspase 8 associated protein 2.	0.504
MYBPHL	CCS	ENSCJAP00000005355	ENSCJAP00000002298	Myosin binding protein H like.	Copper chaperone for superoxide dismutase.	0.495
MYBPHL	MYL7	ENSCJAP00000005355	ENSCJAP00000048581	Myosin binding protein H like.	Myosin light chain 7.	0.671
MYBPHL	NPPA	ENSCJAP00000005355	ENSCJAP00000024692	Myosin binding protein H like.	Natriuretic peptide A.	0.449
MYBPHL	PRPF19	ENSCJAP00000005355	ENSCJAP00000030447	Myosin binding protein H like.	Pre-mRNA-processing factor 19.	0.497
MYBPHL	PSMB4	ENSCJAP00000005355	ENSCJAP00000014051	Myosin binding protein H like.	Proteasome subunit beta; Belongs to the peptidase T1B family.	0.491
MYBPHL	PSRC1	ENSCJAP00000005355	ENSCJAP00000064815	Myosin binding protein H like.	Proline and serine rich coiled-coil 1.	0.476

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Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.859

expected number of edges:

10

PPI enrichment p-value:

0.105

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032957

Inositol trisphosphate metabolic process

4 of 5

3.24

4.19

2.40e-08

GO:0070266

Necroptotic process

4 of 13

2.83

3.59

2.27e-07

GO:0006066

Alcohol metabolic process

5 of 291

1.58

1.61

0.00014

GO:0052746

Inositol phosphorylation

2 of 3

3.16

1.54

0.0017

GO:0032958

Inositol phosphate biosynthetic process

2 of 14

2.5

0.97

0.0167

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000825

Inositol tetrakisphosphate 6-kinase activity

4 of 4

3.34

4.61

4.39e-09

GO:0051766

Inositol trisphosphate kinase activity

4 of 9

2.99

4.26

1.49e-08

GO:0003993

Acid phosphatase activity

3 of 7

2.97

2.88

5.66e-06

GO:0102732

myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

GO:0052726

inositol-1,3,4-trisphosphate 5-kinase activity

2 of 2

3.34

1.83

0.00051

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:30075

Acid phosphatase activity, and Alkaline phosphatase activity

6 of 14

2.97

6.68

3.23e-13

CL:30076

Acid phosphatase activity, and Phosphodiesterase I activity

4 of 7

3.1

4.32

1.27e-08

CL:38050

Inositol trisphosphate kinase activity, and Inositol tetrakisphosphate phosphatase activity

4 of 17

2.71

3.62

1.72e-07

CL:38074

Inositol phosphorylation, and Inositol tetrakisphosphate 5-kinase activity

3 of 5

3.12

2.98

3.89e-06

CL:30089

Alkaline phosphatase activity, and Acid phosphatase activity

2 of 7

2.8

1.41

0.0028

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00730

Thiamine metabolism

4 of 21

2.62

3.84

5.24e-08

map00740

Riboflavin metabolism

3 of 19

2.54

2.8

5.30e-06

map00562

Inositol phosphate metabolism

5 of 169

1.81

2.66

5.39e-07

map04070

Phosphatidylinositol signaling system

4 of 181

1.68

1.89

4.16e-05

map01100

Metabolic pathways

11 of 3242

0.87

0.96

5.24e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1483249

Inositol phosphate metabolism

5 of 70

2.19

3.28

1.94e-07

MAP-196819

Vitamin B1 (thiamin) metabolism

2 of 5

2.94

1.47

0.0022

MAP-1855191

Synthesis of IPs in the nucleus

2 of 7

2.8

1.41

0.0028

MAP-1855167

Synthesis of pyrophosphates in the cytosol

2 of 10

2.64

1.3

0.0042

MAP-196849

Metabolism of water-soluble vitamins and cofactors

3 of 192

1.53

0.79

0.0228

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00149

Calcineurin-like phosphoesterase

3 of 14

2.67

2.15

0.00011

PF05770

Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain

2 of 2

3.34

1.6

0.0013

PF03770

Inositol polyphosphate kinase

2 of 9

2.69

1.15

0.0081

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