STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (616 aa)    
Predicted Functional Partners:
UBXN7
UBX domain-containing protein 7.
   
 0.946
IST1
IST1 factor associated with ESCRT-III.
    
 0.849
CHMP3
Uncharacterized protein.
   
 0.794
ENSCJAP00000064265
Uncharacterized protein.
    
 0.730
ENSCJAP00000067141
Uncharacterized protein.
    
 0.730
UFD1
Uncharacterized protein.
    
 0.726
ATL1
GB1/RHD3-type G domain-containing protein.
   
 
 0.698
YOD1
YOD1 deubiquitinase.
   
 0.684
NPLOC4
Nuclear protein localization protein 4 homolog.
   
 0.669
FAAP100
Fanconi anemia-associated protein of 100 kDa isoform b.
   
 0.667
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
Server load: low (24%) [HD]