CD40LG protein (Callithrix jacchus) - STRING interaction network

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Your Current Organism:

Callithrix jacchus

NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL6	CD4	ENSCJAP00000026460	ENSCJAP00000043597	B-cell lymphoma 6 protein isoform 1.	Ig-like domain-containing protein.	0.730
BCL6	CD40	ENSCJAP00000026460	ENSCJAP00000054885	B-cell lymphoma 6 protein isoform 1.	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	0.765
BCL6	CD40LG	ENSCJAP00000026460	ENSCJAP00000056697	B-cell lymphoma 6 protein isoform 1.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	0.843
BCL6	CD86	ENSCJAP00000026460	ENSCJAP00000015187	B-cell lymphoma 6 protein isoform 1.	Ig-like domain-containing protein.	0.787
BCL6	ICOS	ENSCJAP00000026460	ENSCJAP00000069147	B-cell lymphoma 6 protein isoform 1.	Inducible T cell costimulator.	0.828
BCL6	IFNG	ENSCJAP00000026460	ENSCJAP00000056963	B-cell lymphoma 6 protein isoform 1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.611
BCL6	IL10	ENSCJAP00000026460	ENSCJAP00000034416	B-cell lymphoma 6 protein isoform 1.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.542
BCL6	IL2	ENSCJAP00000026460	ENSCJAP00000064247	B-cell lymphoma 6 protein isoform 1.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.569
BCL6	IL4	ENSCJAP00000026460	ENSCJAP00000024044	B-cell lymphoma 6 protein isoform 1.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.642
BCL6	TNF	ENSCJAP00000026460	ENSCJAP00000053053	B-cell lymphoma 6 protein isoform 1.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.460
CD4	BCL6	ENSCJAP00000043597	ENSCJAP00000026460	Ig-like domain-containing protein.	B-cell lymphoma 6 protein isoform 1.	0.730
CD4	CD40	ENSCJAP00000043597	ENSCJAP00000054885	Ig-like domain-containing protein.	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	0.906
CD4	CD40LG	ENSCJAP00000043597	ENSCJAP00000056697	Ig-like domain-containing protein.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (By similarity). Induces the activation of NF-kappa-B (By similarity). Induces the activation of kinases MAPK8 and PAK2 in T-cells (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of [...]	0.947
CD4	CD86	ENSCJAP00000043597	ENSCJAP00000015187	Ig-like domain-containing protein.	Ig-like domain-containing protein.	0.944
CD4	ICOS	ENSCJAP00000043597	ENSCJAP00000069147	Ig-like domain-containing protein.	Inducible T cell costimulator.	0.908
CD4	IFNG	ENSCJAP00000043597	ENSCJAP00000056963	Ig-like domain-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family.	0.966
CD4	IL10	ENSCJAP00000043597	ENSCJAP00000034416	Ig-like domain-containing protein.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.963
CD4	IL2	ENSCJAP00000043597	ENSCJAP00000064247	Ig-like domain-containing protein.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.961
CD4	IL4	ENSCJAP00000043597	ENSCJAP00000024044	Ig-like domain-containing protein.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family.	0.955
CD4	TNF	ENSCJAP00000043597	ENSCJAP00000053053	Ig-like domain-containing protein.	Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...]	0.947