STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CD46Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity (By similarity). (407 aa)    
Predicted Functional Partners:
C3
Complement C3.
    
 0.977
MSN
Moesin.
    
 0.947
CD59
CD59 glycoprotein preproprotein.
   
 
 0.933
LOC100411501
Uncharacterized protein.
    
 0.903
CFI
Uncharacterized protein; Belongs to the peptidase S1 family.
    
 0.796
THBD
Thrombomodulin.
    
 0.773
SLAMF1
Ig-like domain-containing protein.
   
  
 0.769
SERPING1
Serpin family G member 1; Belongs to the serpin family.
     
 0.765
CXADR
CXADR Ig-like cell adhesion molecule.
    
 
 0.725
CD4
Ig-like domain-containing protein.
    
 0.723
Your Current Organism:
Callithrix jacchus
NCBI taxonomy Id: 9483
Other names: C. jacchus, Callithrix jacchus jacchus, common marmoset, white ear-tufted marmoset, white-tufted-ear marmoset
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