| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MED1 | NCOA1 | ENSCJAP00000015874 | ENSCJAP00000014783 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.793 |
| MED1 | NCOA2 | ENSCJAP00000015874 | ENSCJAP00000074903 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Nuclear receptor coactivator. | 0.664 |
| MED1 | PPARA | ENSCJAP00000015874 | ENSCJAP00000000285 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator-activated receptor alpha. | 0.911 |
| MED1 | PPARD | ENSCJAP00000015874 | ENSCJAP00000050757 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator-activated receptor delta isoform 1. | 0.659 |
| MED1 | PPARG | ENSCJAP00000015874 | ENSCJAP00000048822 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.977 |
| MED1 | RARA | ENSCJAP00000015874 | ENSCJAP00000024723 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Uncharacterized protein. | 0.792 |
| MED1 | RARB | ENSCJAP00000015874 | ENSCJAP00000007139 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoic acid receptor beta isoform 1. | 0.866 |
| MED1 | RXRA | ENSCJAP00000015874 | ENSCJAP00000053089 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoid X receptor alpha. | 0.971 |
| MED1 | RXRB | ENSCJAP00000015874 | ENSCJAP00000040245 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoid X receptor beta. | 0.924 |
| MED1 | RXRG | ENSCJAP00000015874 | ENSCJAP00000008496 | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | Retinoic acid receptor RXR-gamma isoform a. | 0.935 |
| NCOA1 | MED1 | ENSCJAP00000014783 | ENSCJAP00000015874 | Nuclear receptor coactivator. | Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. | 0.793 |
| NCOA1 | NCOA2 | ENSCJAP00000014783 | ENSCJAP00000074903 | Nuclear receptor coactivator. | Nuclear receptor coactivator. | 0.993 |
| NCOA1 | PPARA | ENSCJAP00000014783 | ENSCJAP00000000285 | Nuclear receptor coactivator. | Peroxisome proliferator-activated receptor alpha. | 0.948 |
| NCOA1 | PPARD | ENSCJAP00000014783 | ENSCJAP00000050757 | Nuclear receptor coactivator. | Peroxisome proliferator-activated receptor delta isoform 1. | 0.681 |
| NCOA1 | PPARG | ENSCJAP00000014783 | ENSCJAP00000048822 | Nuclear receptor coactivator. | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] | 0.972 |
| NCOA1 | RARA | ENSCJAP00000014783 | ENSCJAP00000024723 | Nuclear receptor coactivator. | Uncharacterized protein. | 0.916 |
| NCOA1 | RARB | ENSCJAP00000014783 | ENSCJAP00000007139 | Nuclear receptor coactivator. | Retinoic acid receptor beta isoform 1. | 0.894 |
| NCOA1 | RXRA | ENSCJAP00000014783 | ENSCJAP00000053089 | Nuclear receptor coactivator. | Retinoid X receptor alpha. | 0.994 |
| NCOA1 | RXRB | ENSCJAP00000014783 | ENSCJAP00000040245 | Nuclear receptor coactivator. | Retinoid X receptor beta. | 0.920 |
| NCOA1 | RXRG | ENSCJAP00000014783 | ENSCJAP00000008496 | Nuclear receptor coactivator. | Retinoic acid receptor RXR-gamma isoform a. | 0.965 |